Exposure to novelty induces naltrexone-reversible analgesia in rats.
Exposure to novelty induces naltrexone-reversible analgesia in rats.
复制标题
暴露于新奇事物会在大鼠中诱导纳曲酮可逆镇痛。
DOI：
10.1037//0735-7044.101.3.436
复制
发表时间：
1987
影响因子：
1.9
通讯作者：
I. Izquierdo
中科院分区：
文献类型：
--
作者：
B. Siegfried;C. Netto;I. Izquierdo
将大鼠暴露于开阔场地、小盒子或小盒子中的抑制性回避训练2分钟后，用甩尾法测量轻微的镇痛效果。S染毒后10min开始观察镇痛作用，持续时间为10~30min。在之前熟悉测试情况的动物身上没有观察到这种情况，而且注射纳曲酮(0.1 mg/kg)可以逆转这种情况。这些数据表明，新颖性本身就是一个足以激活阿片类药物介导的止痛刺激的刺激。
The exposure of rats for 2 min to an open field, to a small box, or to inhibitory avoidance training in the small box was followed by a mild analgesia measured by the tail-flick method. The analgesia was observed as soon as 10 s after the exposure and lasted between 10 and 30 min. It was not observed in animals previously made familiar with the test situation, and it was reversed by the administration of naltrexone (0.1 mg/kg). The data suggest that novelty per se is a sufficient stimulus to activate an opioid-mediated analgesic stimulus.