The relationship of whole human vertebral body creep to bone density and texture via clinically available imaging modalities.
The relationship of whole human vertebral body creep to bone density and texture via clinically available imaging modalities.
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DOI：
10.1016/j.jbiomech.2022.111021
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发表时间：
2022-04
影响因子：
2.4
通讯作者：
Yeni, Yener N.
中科院分区：
文献类型：
--
作者：
Oravec, Daniel;Kim, Woong;Flynn, Michael J.;Yeni, Yener N.
人类椎骨的蠕变变形在生理负荷水平下累积，并被认为是导致临床可观察到的椎体骨折进展的原因。然而，关于人类椎骨蠕变行为的临床可测量预测指标方面的信息很少。在这项研究中，进行了22个人身体T12椎体的蠕变试验(男13个，女9个；年龄41-90岁)。采用双X射线骨密度仪和高分辨率计算机断层扫描测量相同标本的面骨密度参数和体积骨密度参数。使用数字断层合成(DTS)图像进行图像纹理分析(在低分辨率临床成像中探索松质骨内图像强度的组织)。建立了蠕变特性与骨密度和DTS图像纹理参数之间的多元回归模型。对于标准的临床成像配置，仅包括DTS图像纹理参数的模型通常比那些强制在模型中强制使用骨密度参数的模型更具解释性(调整后的R2为0.14-0.682)。纹理异质性和各向异性的度量被认为是蠕变变形和从蠕变中恢复的最具解释性的成像标志。这些图像纹理的度量可以帮助提供与骨量无关的人体脊椎随时间变化的重要临床可测量指标。
Creep deformation of human vertebrae accumulates under physiological levels of load and is understood to contribute to the progression toward clinically observable vertebral fracture. However, little information is available in terms of clinically measurable predictors of creep behavior in human vertebrae. In this study, creep tests were performed on 22 human cadaveric T12 vertebrae (13 male, 9 female; age 41–90). Areal and volumetric bone density parameters were measured from the same specimens using dual x-ray absorptiometry and high resolution computed tomography. Image textural analyses (which probe the organization of image intensities within the cancellous bone in low resolution clinical imaging) were performed using digital tomosynthesis (DTS) images. Multiple regression models were constructed to examine the relationship between creep properties and bone density and DTS image textural parameters. For the standard clinical imaging configuration, models including DTS derived image textural parameters alone were generally more explanatory (adjusted R2: 0.14–0.682) than those with bone density parameters forced in the models (adjusted R2: 0.17–0.61). Metrics of textural heterogeneity and anisotropy presented as the most explanatory imaging markers for creep deformation and recovery from creep. These metrics of image texture may help provide, independent from bone mass, important clinically measurable indicators of the time dependent deformation of human vertebrae.
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影响因子：
4.1
作者：
Pollintine, Phillip;Luo, Jin;Adams, Michael A.
通讯作者：
Adams, Michael A.
DOI：
10.1016/j.msea.2008.08.040
发表时间：
2009-01-15
影响因子：
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作者：
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影响因子：
3.5
作者：
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