AUTISM AS A STRONGLY GENETIC DISORDER - EVIDENCE FROM A BRITISH TWIN STUDY
AUTISM AS A STRONGLY GENETIC DISORDER - EVIDENCE FROM A BRITISH TWIN STUDY
复制标题
DOI：
10.1017/s0033291700028099
复制
发表时间：
1995-01-01
影响因子：
6.9
通讯作者：
RUTTER, M
中科院分区：
文献类型：
--
作者：
BAILEY, A;LECOUTEUR, A;RUTTER, M
之前的两项关于自闭症双胞胎的流行病学研究表明，自闭症主要是由基因决定的，尽管关于认知和可能的社会异常的更广泛的表型的研究结果是矛盾的。产科和围产期危害也被认为是环境决定的病因因素。第一个英国双胞胎样本被重新检查，第二个自闭症双胞胎样本被招募。在合并样本中，60%的同卵（MZ）对与非异卵（DZ）对在自闭症方面是一致的；92%的MZ对在更广泛的相关认知或社会异常方面是一致的，而DZ对只有10%。研究结果表明，自闭症受到高度的遗传控制，可能涉及多个遗传位点。产科危险通常似乎是遗传影响的异常发育的后果，而不是独立的病因因素。很少有新病例有可能的医学病因，驳斥了公认的疾病是常见病因影响的说法。
Two previous epidemiological studies of autistic twins suggested that autism was predominantly genetically determined, although the findings with regard to a broader phenotype of cognitive, and possibly social, abnormalities were contradictory. Obstetric and perinatal hazards were also invoked as environmentally determined aetiological factors. The first British twin sample has been re-examined and a second total population sample of autistic twins recruited. In the combined sample 60% of monozygotic (MZ) pairs were concordant for autism versus no dizygotic (DZ) pairs; 92% of MZ pairs were concordant for a broader spectrum of related cognitive or social abnormalities versus 10% of DZ pairs. The findings indicate that autism is under a high degree of genetic control and suggest the involvement of multiple genetic loci. Obstetric hazards usually appear to be consequences of genetically influenced abnormal development, rather than independent aetiological factors. Few new cases had possible medical aetiologies, refuting claims that recognized disorders are common aetiological influences.