Phosphate Homeostasis in CKD: Report of a Scientific Symposium Sponsored by the National Kidney Foundation
Phosphate Homeostasis in CKD: Report of a Scientific Symposium Sponsored by the National Kidney Foundation
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DOI：
10.1053/j.ajkd.2013.03.042
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发表时间：
2013-09-01
影响因子：
13.2
通讯作者：
Wheeler, David C.
中科院分区：
文献类型：
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作者：
Block, Geoffrey A.;Ix, Joachim H.;Wheeler, David C.
慢性肾脏病（CKD）-矿物质和骨骼疾病与多种代谢和内分泌紊乱相关，最终可能导致肾功能进一步丧失、骨脱矿和致死性或非致死性心血管事件。最近对这种疾病发展过程中发生的事件的病理生理学的了解表明，磷酸盐代谢紊乱是关键。在估计肾小球滤过率时，磷酸盐稳态异常的后果是明显的
Chronic kidney disease (CKD)-mineral and bone disorder is associated with diverse metabolic and endocrine disturbances that ultimately may contribute to further loss of kidney function, bone demineralization, and fatal or nonfatal cardiovascular events. Recent insights into the pathophysiology of the events that unfold during the development of this disorder suggest that disturbances in phosphate metabolism are pivotal. The consequences of abnormal phosphate homeostasis are evident at estimated glomerular filtration rates