Cytokeratin and vimentin expression in breast cancer
Cytokeratin and vimentin expression in breast cancer
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DOI：
10.1177/172460080902400106
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发表时间：
2009-01-01
影响因子：
2
通讯作者：
Shah, Pankaj M.
中科院分区：
文献类型：
--
作者：
Vora, Hemangini H.;Patel, Nupur A.;Shah, Pankaj M.
背景资料：从上皮角蛋白到间充质波形蛋白表达的转变标志着乳腺癌恶性进展的重要一步。材料与方法：采用免疫组化方法检测乳腺癌石蜡包埋组织中细胞角蛋白（cytokeratin）和波形蛋白（vimentin）的表达，分析其在乳腺癌中的临床意义。在IV期疾病和PR阴性患者中观察到细胞角蛋白丢失的明显趋势。弱细胞角蛋白表达存在于复发或转移性疾病的患者中。在单因素和多因素分析中，细胞角蛋白的缺失与总生存率的降低相关，波形蛋白表达的增加见于57%的乳腺癌患者。淋巴结阳性、晚期、HER 2阳性、肿瘤复发或转移患者的阳性率较高。多因素生存分析表明，波形蛋白表达的增益与减少无复发survival.Conclusion：细胞角蛋白的损失和波形蛋白表达的增益是生物学侵袭性乳腺癌的指标。(Int J Biol Markers 2009; 24：38-46）
Background: The transition from epithelial keratin to mesenchymal vimentin expression marks an important step in the malignant progression of breast cancer. This study analyzed the clinical significance of cytokeratin and vimentin in patients with breast cancer.Materials and methods: Expression of cytokeratin and vimentin was evaluated by immunohistochemistry on paraffin-embedded tissue sections of patients with breast cancer.Results: Loss of cytokeratin was seen in 11% of the patients. A clearer trend towards loss of cytokeratin was observed in patients with stage IV disease and PR negativity. Weak cytokeratin expression was present in patients who developed recurrence or metastatic disease. Loss of cytokeratin was associated with reduced overall survival in univariate and multivariate analysis, gain of vimentin expression was seen in 57% of breast carcinoma patients. It was higher in patients with lymph node positivity, advanced stage, HER2 positivity, and disease recurrence or metastasis. Multivariate survival analysis indicated that gain of vimentin expression was associated with reduced relapse-free survival.Conclusion: Loss of cytokeratin and gain of vimentin expression are indicators of biologically aggressive breast carcinoma. (Int J Biol Markers 2009; 24: 38-46)