The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions
The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions
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DOI：
10.1023/b:clin.0000037703.37275.35
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发表时间：
2004-01-01
影响因子：
4
通讯作者：
Kopolovic, J
中科院分区：
文献类型：
--
作者：
Davidson, B;Goldberg, I;Kopolovic, J
Ets转录因子通过调节蛋白水解酶和血管生成分子的合成，在肿瘤的侵袭和转移过程中发挥重要作用。本研究的目的是探讨PEA 3在卵巢癌和乳腺癌积液转移中的作用，并评估Ets-2和Erg在卵巢癌中的表达。使用mRNA原位杂交（ISH）评估卵巢癌（83例恶性积液，102例相应的实体病变）和乳腺癌（33例恶性积液，40例相应的实体病变）的PEA 3表达。用同样的方法检测50例卵巢癌积液中Ets-2和Erg mRNA的表达。PEA 3 mRNA表达在卵巢癌的所有部位都相当（44/83; 53%的积液，48/102; 47%的实体瘤）。渗出液中PEA 3 mRNA表达与先前研究的α V（P=0.022）、α 6（P
Ets transcription factors play a central role in invasion and metastasis through regulation of synthesis of proteolytic enzymes and angiogenic molecules. The objective of this study was to investigate the role of PEA3 in tumor progression of ovarian and breast carcinoma metastatic to effusions, and to evaluate the expression of Ets-2 and Erg in ovarian carcinoma. Ovarian (83 malignant effusions, 102 corresponding solid lesions) and breast (33 malignant effusions, 40 corresponding solid lesions) carcinomas were evaluated for expression of PEA3 using mRNA in situ Hybridization (ISH). Expression of Ets-2 and Erg mRNA was analyzed in 50 ovarian carcinoma effusions using the same method. PEA3 mRNA expression was comparable at all sites in ovarian carcinoma (44 out of 83; 53% of effusions, 48 out of 102; 47% of solid tumors). PEA3 mRNA expression in effusions correlated with mRNA expression of the previously studied alphaV (P=0.022), alpha6 (P