Transient inactivation of orbitofrontal cortex blocks reinforcer devaluation in macaques.
Transient inactivation of orbitofrontal cortex blocks reinforcer devaluation in macaques.
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DOI：
10.1523/jneurosci.3295-11.2011
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发表时间：
2011-10-19
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影响因子：
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通讯作者：
Malkova L
中科院分区：
文献类型：
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作者：
West EA;DesJardin JT;Gale K;Malkova L
眶额皮层（OFC）及其与基底外侧杏仁核（BLA）的相互作用对目标导向行为至关重要，特别是对于适应奖励价值的变化。在这里，我们使用了一个更好的贬值范式，调查OFC的贡献，这一行为在四只猕猴。在物体和两种不同的主要食物（食物）之间形成联系的受试者被要求选择覆盖在两种不同食物上的物体。当两种食物中的一种因选择性饱食而贬值时，受试者将他们的选择转向代表未饱食食物奖励的物体（贬值效应）。将GABAA受体激动剂蝇蕈醇注入13区，使OFC暂时失活，阻断了贬值效应：猴子并没有减少对与贬值食物相关的物体的选择。这种效果被观察到时，OFC在饱食和选择测试，并在选择测试期间被灭活。这支持了我们的假设，OFC活动是必需的在饱腹感对象选择期间，以指导对象的选择。这一发现与BLA在同一贬值过程中的作用形成鲜明对比。尽管在选择性饱足过程中需要BLA的活动，但它并不需要指导随后的对象选择。我们的研究结果是第一个证明，OFC的瞬时失活是足以破坏贬值效应，并记录的作用OFC不同的BLA的条件反射器贬值过程中的猴子。
The orbitofrontal cortex (OFC) and its interactions with the basolateral amygdala (BLA) are critical for goal-directed behavior, especially for adapting to changes in reward value. Here we used a reinforcer devaluation paradigm to investigate the contribution of OFC to this behavior in four macaques. Subjects that had formed associations between objects and two different primary reinforcers (foods) were presented with choices of objects overlying the two different foods. When one of the two foods was devalued by selective satiation, the subjects shifted their choices toward the objects that represented the nonsated food reward (devaluation effect). Transient inactivation of OFC by infusions of the GABAA receptor agonist muscimol into area 13 blocked the devaluation effect: the monkeys did not reduce their selection of objects associated with the devalued food. This effect was observed when OFC was inactivated during both satiation and the choice test, and during the choice test only. This supports our hypothesis that OFC activity is required during the postsatiety object choice period to guide the selection of objects. This finding sharply contrasts with the role of BLA in the same devaluation process. Whereas activity in BLA was required during the selective satiation procedure, it was not necessary for guiding the subsequent object choice. Our results are the first to demonstrate that transient inactivation of OFC is sufficient to disrupt the devaluation effect, and to document a role for OFC distinct from that of BLA for the conditioned reinforcer devaluation process in monkeys.