Circadian elevation of IL-6 levels in Muckle-Wells syndrome: a disorder of the neuro-immune axis?
Circadian elevation of IL-6 levels in Muckle-Wells syndrome: a disorder of the neuro-immune axis?
复制标题
DOI：
10.1093/qjmed/91.7.489
复制
发表时间：
1998-07-01
影响因子：
13.3
通讯作者：
Hunziker, T
中科院分区：
文献类型：
--
作者：
Gerbig, AW;Dahinden, CA;Hunziker, T
Muckle-Wells综合征(MWS)是一种罕见的常染色体显性遗传性疾病，以慢性复发性荨麻疹、关节痛、感音神经性耳聋为特征，有时还可由淀粉样变性肾病(AA型)引起。我们报告了一位21岁的女性和她的父亲，都患有这种综合征，在荨麻疹发作期间可以记录到血清IL-6水平的升高，并讨论了这一发现与MWS的相关性。
Muckle-Wells syndrome (MWS) is a rare autosomal dominant hereditary disorder characterized by chronic recurrent urticaria, arthralgia, sensorineural deafness, and in some cases nephropathy due to amyloidosis (AA type). We report a 21-year-old woman and her father, both suffering from this syndrome, in whom elevated serum levels of IL-6 could be documented during the flares of urticaria, and discuss the relevance of this finding for MWS.