Seroprevalence and correlates of hepatitis A among HIV-negative American men who have sex with men
Seroprevalence and correlates of hepatitis A among HIV-negative American men who have sex with men
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DOI：
10.1071/sh10162
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发表时间：
2011-01-01
期刊：
影响因子：
1.6
通讯作者：
Celentano, David D.
中科院分区：
文献类型：
--
作者：
Bialek, Stephanie R.;Barry, Vaughn;Celentano, David D.
背景：甲型肝炎在男男性行为者 (MSM) 中暴发已有充分记录。该分析调查了来自美国五个城市的一大群年轻 MSM 中与甲型肝炎病毒 (HAV) 感染相关的特征。方法：青年男性调查是一项1994-2000年间15-29岁MSM中HIV感染和相关行为危险因素的横断面流行率研究。对 HIV 阴性参与者的血清样本进行了回顾性检测，以检测 HAV 抗体（抗 HAV）。数据按种族分层并用逻辑回归进行分析。结果：2708 名参与者中，总体抗 HAV 患病率为 18.4%，不同种族的患病率从 6.9% 到 45.3% 不等，其中西班牙裔和亚洲男性最高（P < 0.001）。在所有种族/族裔群体中，患病率随着年龄的增长而增加。在白人男性中，15-22 岁的白人男性中，抗 HAV 阳性与一生中有 20 个或更多男性性伴侣相关（调整后优势比 (AOR) = 2.1，95% 置信区间 (CI) = 1.0-4.1），23-29 岁的人群曾经有过无保护的肛交（AOR = 2.4，95% CI = 1.2-4.5）。结论：非疫情地区 MSM 中与 HAV 感染史相关的因素可能与非 MSM 中的相似。由于 MSM 社区中爆发了 HAV，MSM 仍然面临感染 HAV 的风险。需要对甲型肝炎疫苗接种覆盖率进行更多研究，以确定 MSM 疫苗接种策略是否足够。
Background: Hepatitis A outbreaks are well documented among men who have sex with men (MSM). This analysis examines characteristics associated with hepatitis A virus (HAV) infection among a large group of young adult MSM from five USA cities. Methods: The Young Men's Survey was a cross-sectional prevalence study of HIV infection and related behavioural risk factors among MSM aged 15-29 years during 1994-2000. Serum specimens from HIV-negative participants were retrospectively tested for antibodies to HAV (anti-HAV). Data were stratified by ethnicity and analysed with logistic regression. Results: Overall anti-HAV prevalence was 18.4% among the 2708 participants, and varied by ethnicity from 6.9 to 45.3% and was highest among Hispanic and Asian men (P < 0.001). Prevalence increased with age across all racial/ethnic groups. Among white men, anti-HAV positivity was associated with having 20 or more lifetime male sex partners for those aged 15-22 years (adjusted odds ratio (AOR) = 2.1, 95% confidence interval (CI) = 1.0-4.1) and ever having had unprotected anal sex for those aged 23-29 years (AOR = 2.4, 95% CI = 1.2-4.5). Conclusions: Factors associated with a history of HAV infection among MSM in non-outbreak settings are probably similar to those among non-MSM. MSM are still at risk for HAV infection as a result of outbreaks occurring in MSM communities. Additional studies of hepatitis A vaccination coverage are needed to determine if strategies to vaccinate MSM are adequate.