Radial glial cells in the adult dentate gyrus: what are they and where do they come from?
Radial glial cells in the adult dentate gyrus: what are they and where do they come from?
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DOI：
10.12688/f1000research.12684.1
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Song H
中科院分区：
文献类型：
--
作者：
Berg DA;Bond AM;Ming GL;Song H
成年神经发生在哺乳动物海马的齿状回。这些新的神经元来自于位于齿状回亚颗粒区被称为放射状胶质样细胞的神经前体细胞。在这里，我们回顾了成体亚颗粒带前体异质性的新兴主题。我们还讨论了这种异质性是如何在发育过程中建立的，并重点关注齿状回和放射状胶质样干细胞的胚胎起源。最后，我们讨论了最近发展的单细胞技术，我们认为这将是全面研究成体神经干细胞起源和异质性的关键。
Adult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus. Here, we review the emerging topic of precursor heterogeneity in the adult subgranular zone. We also discuss how this heterogeneity may be established during development and focus on the embryonic origin of the dentate gyrus and radial glia-like stem cells. Finally, we discuss recently developed single-cell techniques, which we believe will be critical to comprehensively investigate adult neural stem cell origin and heterogeneity.