Top 10 Recent Developments in Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus
Top 10 Recent Developments in Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus
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DOI：
10.1007/s11926-013-0380-9
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发表时间：
2013-12-01
影响因子：
5
通讯作者：
Jolly, Meenakshi
中科院分区：
文献类型：
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作者：
Dua, Anisha B.;Touma, Zahi;Jolly, Meenakshi
系统性红斑狼疮(SLE)是一种影响健康相关生活质量(HRQOL)的慢性自身免疫性疾病。改善对SLE的监测和管理可提高存活率；然而，改善这些患者的HRQOL仍然是最重要的。HRQL测量已被推荐用于临床实践和研究，包括药物开发和临床试验中的测试。已经开发了通用仪器和疾病特异性仪器来确定HRQL。在日益全球化的协作环境中，跨国家评估HRQL的重要性、对其混杂因素的认识以及所用工具的局限性至关重要。在这里，我们回顾了过去5年的一些主要进展，重点是：测量SLE患者HRQL的重要性，现有工具的优点和局限性，以及它们在研究环境中的应用。
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that has major implications for health-related quality of life (HRQoL). Improvements in the monitoring and management of SLE improves survival; however, improvement of HRQoL remains of paramount importance among these patients. Measurement of HRQoL has been recommended in clinical practice and research including drug development and testing in clinical trials. Both generic and disease specific instruments have been developed to ascertain HRQoL. In an increasingly global collaborative environment, the importance of assessing HRQoL across nations, acknowledgment of their confounders, and limitations of used instruments are critical. Here, we review selected major developments in the past 5 years highlighting: the importance of measuring HRQoL in SLE patients, the benefits and limitations of instruments that exist, and their application in research settings.