The Anatomy of the Mesolimbic Reward System: A Link between Personality and the Placebo Analgesic Response
The Anatomy of the Mesolimbic Reward System: A Link between Personality and the Placebo Analgesic Response
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DOI：
10.1523/jneurosci.5634-08.2009
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发表时间：
2009-04-15
影响因子：
5.3
通讯作者：
Bushnell, M. Catherine
中科院分区：
文献类型：
--
作者：
Schweinhardt, Petra;Seminowicz, David A.;Bushnell, M. Catherine
临床获益的预期是安慰剂镇痛的一个重要组成部分，被认为是奖励预期的一个特例。由于奖励处理与腹侧纹状体和神经递质多巴胺密切相关，我们研究了大脑灰质，安慰剂镇痛反应和与多巴胺能神经传递相关的人格特质之间的关系。我们报告说，多巴胺相关的性状预测一个人从假治疗中获得的疼痛缓解的相当大的一部分。基于体素的磁共振图像的形态学显示，安慰剂镇痛的幅度与几个脑区的灰质密度（GMD）有关，包括腹侧纹状体、纹状体和前额叶皮质。同样，腹侧纹状体和前额叶皮层的GMD与多巴胺相关的人格特质有关。我们的研究结果突出了安慰剂和奖励之间的关系，并可能提供识别可能显示大安慰剂镇痛反应的受试者的方法。
The anticipation of clinical benefit, a crucial component of placebo analgesia, has been suggested to be a special case of reward anticipation. Since reward processing is closely linked to the ventral striatum and the neurotransmitter dopamine, we examined the relationships between brain gray matter, placebo analgesic response, and personality traits associated with dopaminergic neurotransmission. We report that dopamine-related traits predict a substantial portion of the pain relief an individual gains from a sham treatment. Voxel-based morphometry of magnetic resonance images shows that the magnitude of placebo analgesia is related to gray matter density(GMD) in several brain regions, including the ventral striatum, insula, and prefrontal cortex. Similarly, GMD in ventral striatum and prefrontal cortex is related to dopamine-related personality traits. Our findings highlight the relationship between placebo and reward and potentially offer ways of identifying subjects who are likely to show large placebo analgesic responses.