Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-amyloid Plaques.

Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-amyloid Plaques.
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发现具有柔性接头的二苯氧基衍生物作为 β-淀粉样斑块的配体。

DOI:
10.1021/acs.molpharmaceut.0c00537
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发表时间:
2020-08
影响因子:
4.9
通讯作者:
Cui Mengchao
Cui Mengchao
中科院分区:
医学2区
文献类型:
--
作者:
Jia Jianhua;Zhang Longfei;Song Jia;Dai Jiapei;Cui Mengchao

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具有π共轭系统的高刚性平面支架被广泛认为是Aβ结合配体不可或缺的。在本研究中,合成了具有不同类型的更灵活的连接体作为 Aβ 配体的二苯氧基化合物库
The highly rigid and planar scaffolds with π-conjugated systems have been widely considered to be indispensable for Aβ binding ligands. In this study, a library of diphenoxy compounds with different types of more flexible linkers as Aβ ligands were synthe
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