The role of OX40-mediated co-stimulation in T-cell activation and survival.
The role of OX40-mediated co-stimulation in T-cell activation and survival.
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DOI：
10.1615/critrevimmunol.v29.i3.10
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发表时间：
2009
影响因子：
1.3
通讯作者：
Weinberg AD
中科院分区：
文献类型：
--
作者：
Redmond WL;Ruby CE;Weinberg AD
T细胞受体连接后的T细胞活化、增殖和存活的程度由几个因素控制，包括TCR刺激的强度、促存活细胞因子的可用性和共刺激信号的存在或不存在。除了通过其天然配体B7.1（CD80）和B7.2（CD86）接合CD28共刺激受体之外，最近的工作已经开始阐明通过TNFR超家族的成员OX40（CD134）共刺激受体的信号传导影响T细胞应答的机制。重要的是，已经显示0X40连接增强⑶ 4和⑶ 8 T细胞克隆扩增、效应分化、存活，并且在某些情况下，消除调节性FoxP3+CD25+CD4+ T细胞的抑制活性。在这篇综述中，我们将重点关注调节活化T细胞上OX40表达的机制以及OX40介导的共刺激在促进T细胞克隆扩增、效应分化和存活中的作用。
The extent of T cell activation, proliferation, and survival that follows T cell receptor ligation is controlled by several factors including the strength of TCR stimulation, the availability of pro-survival cytokines, and the presence or absence of co-stimulatory signals. In addition to engagement of the CD28 co-stimulatory receptor by its natural ligands, B7.1 (CD80) and B7.2 (CD86), recent work has begun to elucidate the mechanisms by which signaling through the OX40 (CD134) co-stimulatory receptor, a member of the TNFR super-family, affects T cell responses. Importantly, OX40 ligation has been shown to augment CD4 and CD8 T cell clonal expansion, effector differentiation, survival, and in some cases, abrogate the suppressive activity of regulatory FoxP3+CD25+CD4+ T cells. In this review, we will focus on the mechanisms regulating OX40 expression on activated T cells as well as the role of OX40-mediated co-stimulation in boosting T cell clonal expansion, effector differentiation, and survival.
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