Small molecular inhibitor of transforming growth factor-β protects against development of radiation-induced lung injury
Small molecular inhibitor of transforming growth factor-β protects against development of radiation-induced lung injury
复制标题
DOI：
10.1016/j.ijrobp.2008.02.046
复制
发表时间：
2008-07-01
影响因子：
7
通讯作者：
Vujaskovic, Zeljko
中科院分区：
文献类型：
--
作者：
Anscher, Mitchell S.;Thrasher, Bradley;Vujaskovic, Zeljko
目的：为了确定是否有抗转化生长因子-β（TGF-β）1型受体抑制剂（SM 16）可以防止辐射诱导的lung injury.Methods and Materials：一个分数的28戈伊或假放射治疗（RT）的Sprague-Dawley大鼠右半胸。在大鼠饲料中给予SM 16将大鼠分为8组：1组，对照饲料; 2组，SM 16，0.07 g/kg; 3组，SM 16，0.15 g/kg; 4组，RT+对照饲料; 5组，RT + SM 16，0.07 g/kg;第6组，RT加SM 16，0.15 g/kg;第7组，RT加3周SM 16 0.07 g/kg，随后为对照食物;第8组，RT加3周SM 16 0.15 g/kg，随后为对照食物。结果：从第10-22周开始，RT + SM 16 0.15 g/kg组的呼吸频率显著低于RT+对照组（p
Purpose: To determine whether an anti-transforming growth factor-beta (TGF-beta) type 1 receptor inhibitor (SM16) can prevent radiation-induced lung injury.Methods and Materials: One fraction of 28 Gy or sham radiotherapy (RT) was administered to the right hemithorax of Sprague-Dawley rats. SM16 was administered in the rat chow (0.07 g/kg or 0.15 g/kg) beginning 7 days before RT. The rats were divided into eight groups: group 1, control chow; group 2, SM16, 0.07 g/kg; group 3, SM16, 0.15 g/kg; group 4, RT plus control chow; group 5, RT plus SM16, 0.07 g/kg; group 6, RT plus SM16, 0.15 g/kg; group 7, RT plus 3 weeks of SM16 0.07 g/kg followed by control chow; and group 8, RT plus 3 weeks of SM16 0.15 g/kg followed by control chow. The breathing frequencies, presence of inflammation/fibrosis, activation of macrophages, and expression/activation of TGF-beta were assessed.Results: The breathing frequencies in the RT plus SM16 0.15 g/kg were significantly lower than the RT plus control chow from Weeks 10-22 (p