DEFENSIVE REACTIONS EVOKED BY ACTIVATION OF NMDA RECEPTORS IN DISTINCT SITES OF THE INFERIOR COLLICULUS
DEFENSIVE REACTIONS EVOKED BY ACTIVATION OF NMDA RECEPTORS IN DISTINCT SITES OF THE INFERIOR COLLICULUS
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DOI：
10.1016/0166-4328(94)90046-9
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发表时间：
1994-07-29
影响因子：
2.7
通讯作者：
BRANDAO, ML
中科院分区：
文献类型：
--
作者：
CARDOSO, SH;COIMBRA, NC;BRANDAO, ML
下丘（IC）主要参与将听觉信息传递到更高的皮层结构。最近，我们已经表明，这种结构也可能是指挥防御行为的大脑系统的一部分。有证据表明，负责下丘防御行为的神经底物受GABA能、多巴胺能和阿片类机制调节，这些底物也可能被苯二氮卓类药物抑制，作为其抗焦虑作用的一部分。在这里，我们提出的证据参与兴奋性氨基酸在IC中的防御反应的表达。将NMDA（5-40 nmol）-一种兴奋性氨基酸-微量注射到置于圆形竞技场内的大鼠IC中央核的腹外侧区中，诱导厌恶反应，其特征为奔跑、直立和跳跃。这种活动过度被不动状态所分散，不动状态通常进展为惊厥性癫痫发作。这些反应被预先微量注射到IC中的NMDA特异性拮抗剂AP 7抑制。这表明，NMDA受体介导的机制被称为发挥防御行为的显示过程中。
The inferior colliculus (IC) is primarily involved in conveying auditory information to higher cortical structures. Recently we have shown that this structure may also be part of a brain system commanding defensive behaviour. There is evidence that the neural substrates responsible for defensive behaviour in the inferior colliculus are regulated by GABAergic, serotonergic and opioid mechanisms and that these substrates may also be depressed by benzodiazepines as part of their anxiolytic action. Here we present evidence for the involvement of excitatory amino acids in the IC in the expression of defensive reactions. Microinjections of NMDA (5-40 nmol) - an excitatory amino acid - into the ventrolateral division of the central nucleus of the IC of rats placed inside a circular arena induced aversive reactions, characterized by running, rearing, and jumping. This hyperactivity was interspersed by immobility states which often progressed to convulsive seizures. These reactions were inhibited by the NMDA specific antagonist AP7 previously microinjected into the IC. It is suggested that NMDA receptor mediated mechanisms are called into play during the display of the defensive behaviour.