Count-based PET method for predicting ischemic stroke in patients with symptomatic carotid arterial occlusion
Count-based PET method for predicting ischemic stroke in patients with symptomatic carotid arterial occlusion
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DOI：
10.1148/radiology.212.2.r99au27499
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发表时间：
1999-08-01
期刊：
影响因子：
19.7
通讯作者：
Powers, WJ
中科院分区：
文献类型：
--
作者：
Derdeyn, CP;Videen, TO;Powers, WJ
目得：为了测试基于计数的正电子发射断层扫描（PET）方法在没有动脉采样的情况下测量局部脑氧摄取分数（OEF）预测有症状的颈动脉闭塞患者缺血性卒中的能力。材料和方法：一项设盲前瞻性研究的结果分析旨在确定OEF增加是否是有症状和有症状患者卒中的独立预测因子，通过用基于计数的OEF测量方法代替原始定量技术来重复颈动脉闭塞。使用Kaplan-Meier累积生存函数（对数秩，[P < .05]）评估定量和基于计数的方法的性能。两种方法的受试者工作特征（ROC）曲线generated.RESULTS：13同侧中风发生在平均随访3.1年的81例患者。所有同侧卒中均发生在50例OEF计数增加的患者中（P = 0.002，灵敏度100%，特异性46%）。68例患者进行了完整的定量研究，允许比较OEF方法。在该亚组中，基于计数的方法和定量方法均能预测卒中（分别为P = 0.005和0.025）。ROC分析表明，更大的曲线下面积为计数为基础的OEFmethod.CONCLUSION：计数为基础的PET测量OEF动脉采样准确预测中风患者颈动脉闭塞。
PURPOSE: To test the ability of a count-based positron emission tomographic (PET) method, without arterial sampling, for the measurement of regional cerebral oxygen extraction fraction (OEF) to predict ischemic stroke in patients with symptomatic carotid arterial occlusion.MATERIALS AND METHODS: The outcome analysis of a blinded prospective study designed to determine if increased OEF was an independent predictor of stroke in patients with symptoms and with carotid occlusion was repeated by substituting a count-based method of OEF measurement for the original quantitative technique. The performance of the quantitative and count-based methods was assessed by using Kaplan-Meier cumulative survival functions (log-rank, [P < .05]). Receiver operating characteristic (ROC) curves for both methods were generated.RESULTS: Thirteen ipsilateral strokes occurred during a mean follow-up of 3.1 years for 81 patients. All ipsilateral strokes occurred in 50 patients with increased count-based OEF (P = .002, sensitivity 100%, specificity 46%). Sixty-eight patients underwent complete quantitative studies, which allowed comparison of OEF methods. Both the count-based and the quantitative methods were predictive of stroke in this subgroup (P = .005 and .025, respectively). ROC analysis demonstrated a greater area under the curve for the count-based OEF method.CONCLUSION: Count-based PET measurement of OEF without arterial sampling accurately predicts stroke in patients with carotid occlusion.