Inverse U-shaped Association between Sleep Duration and Semen Quality: Longitudinal Observational Study (MARHCS) in Chongqing, China
Inverse U-shaped Association between Sleep Duration and Semen Quality: Longitudinal Observational Study (MARHCS) in Chongqing, China
复制标题
睡眠持续时间与精液质量之间的倒 U 形关联：中国重庆的纵向观察研究 (MARHCS)。
作者：
Chen, Qing;Yang, Huan;Cao, Jia
研究目的：研究睡眠时间与精液参数及生殖激素水平的关系。2013年共招募了796例受试者，2014年共随访了656例（82.4%）。每次采集精液和外周血样本，用于精液质量和生殖激素测定。睡眠时间采用修订的慕尼黑时间类型问卷进行评估。2014年，睡眠质量也被匹兹堡睡眠质量指数（PSQI）测量。结果：睡眠时间与两个精液参数（精液量和精子总数）之间存在实质性的倒U形相关，其中7.0-7.5 h/天的睡眠显示出最高参数。无论是较长或较短的睡眠与精液参数下降的剂量反应方式（P = 0.002和0.001，分别）。睡眠时间> 9.0小时与精液量减少21.5%（95%置信区间9.2，32.2）和精子总数减少39.4%（23.3，52.1）相关;睡眠时间> 9.0小时与精液量减少21.5%（95%置信区间9.2，32.2）和精子总数减少39.4%（95%置信区间23.3，52.1）相关。
Study Objectives: To investigate the association between sleep duration and semen parameters as well as reproductive hormone levels.Methods: We designed a cohort of male college students in Chongqing, China. A total of 796 subjects were recruited in 2013 and 656 (82.4%) were followed up in 2014. Each time, semen and peripheral blood samples were collected for semen quality and reproductive hormone measurement. Sleep duration was estimated by revised Munich Chronotype Questionnaire. In 2014, sleep quality was also measured by Pittsburgh Sleep Quality Index (PSQI).Results: There was a substantial inverse U-shaped association between sleep duration and two semen parameters (semen volume and total sperm number), with 7.0-7.5 h/day of sleep showing highest parameters. Either longer or shorter sleep was associated with decreased semen parameters in a dose-response manner (P = 0.002 and 0.001, respectively). Sleeping > 9.0 h was associated with a 21.5% (95% confidence interval 9.2, 32.2) reduction in semen volume and 39.4% (23.3, 52.1) reduction in total sperm number; sleeping