A novel interaction between dietary composition and insulin secretion: effects on weight gain in the Quebec Family Study
A novel interaction between dietary composition and insulin secretion: effects on weight gain in the Quebec Family Study
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DOI：
10.1093/ajcn/87.2.303
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发表时间：
2008-02-01
影响因子：
7.1
通讯作者：
Ludwig, David S.
中科院分区：
文献类型：
--
作者：
Chaput, Jean-Philippe;Tremblay, Angelo;Ludwig, David S.
背景资料：低脂肪饮食的临床试验的特点是产生小的平均长期体重减轻，但在响应中有很大的个体间差异。这种差异被归因于心理和行为因素，尽管生物学差异也可能发挥作用。目的：目的是确定胰岛素分泌的生理差异是否可以解释食用低脂肪和高脂肪饮食的个体之间体重增加的差异。设计：在魁北克家庭研究的276个个体中，平均随访6年，我们比较了最低和最高膳食脂肪三分位数的个体。我们在基线时进行口服葡萄糖耐量试验，并检查30分钟时的胰岛素浓度（胰岛素-30）作为胰岛素分泌的替代指标。体重和腰围的6年变化是主要终点。我们通过线性回归分析确定了胰岛素-30和主要终点之间的相关性，并对潜在的混杂因素进行了调整。结果：体重和腰围的平均变化在最低和最高脂肪饮食组之间没有显著差异。然而，这些终点与胰岛素-30密切相关，特别是在食用最低脂肪饮食的个体中。在最低饮食脂肪组（r = 0.18，P = 0.086），基线胰岛素-30与6年体重增加（r = 0.51，P <0.0001）和腰围变化（r = 0.55，P < 0.0001）显著相关，但在最高饮食脂肪组（r = 0.20，P = 0.058）不相关。最高胰岛素-30和最低膳食脂肪组的个体比最高胰岛素-30和最高膳食脂肪组的个体多增重1.8公斤（51%; P = 0.034）;他们比最低胰岛素-30和最低膳食脂肪组多增重4.5 kg结论：胰岛素分泌的替代指标可以很好地预测6年以上成年人体重和腰围的变化，尤其是那些食用低脂饮食的人，这表明存在一种新的饮食-表型相互作用。
Background: Clinical trials of low-fat diets characteristically produce small mean long-term weight loss but a large interindividual variation in response. This variation has been attributed to psychological and behavioral factors, although biological differences may also play a role.Objective: The objective was to determine whether physiologic differences in insulin secretion explain differences in weight gain among individuals consuming low- and high-fat diets.Design: Of 276 individuals followed in the Quebec Family Study for a mean of 6 y, we compared those in the lowest with those in the highest dietary fat tertiles. We performed oral-glucose-tolerance tests at baseline and examined the insulin concentration at 30 min (insulin-30) as a proxy measure of insulin secretion. Six-year changes in body weight and waist circumference were the primary endpoints. We determined the associations between insulin-30 and the primary endpoints by linear regression analysis, with adjustment for potentially confounding factors.Results: Mean changes in body weight and waist circumference did not differ significantly between the lowest- and highest-fat diet groups. However, these endpoints were strongly associated with insulin-30, especially among individuals consuming the lowest-fat diet. Insulin-30 at baseline was significantly associated with 6-y weight gain (r = 0.5 1, P < 0.0001) and change in waist circumference (r = 0.55, P < 0.0001) in the lowest diet fat, group (r = 0.18, P = 0.086), but not in the highest diet fat group (r = 0.20, P = 0.058). Individuals in the highest insulin-30 and lowest dietary fat group gained 1.8 kg more than did those in the highest insulin-30 and highest dietary fat group (51%; P = 0.034); they gained 4.5 kg more than did those in the lowest insulin-30 and lowest dietary fat group (6.5-fold; P = 0.0026).Conclusion: A proxy measure of insulin secretion strongly predicts changes in body weight and waist circumference over 6 y in adults, especially among those consuming lower-fat diets, which demonstrates the existence of a novel diet-phenotype interaction.