Destruction of the intestinal mucosa after bone marrow transplantation and graft-versus-host disease.
Destruction of the intestinal mucosa after bone marrow transplantation and graft-versus-host disease.
复制标题
骨髓移植和移植物抗宿主病后肠粘膜的破坏。
DOI：
10.1159/000156931
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Beschorner,WE
中科院分区：
文献类型：
--
作者：
Beschorner,WE
Due to many recenl advances, allogeneic bone marrow transplantation now provides an effective means for curing patients with severe aplastic anemia and acute leukemia as well as correcting congenital immune and enzyme deficiencies [1-3). In spite of these advances, however, acute and chronic graftversus-host disease (GVHD) are still frequent complications and contribute significantly to the overall mortality. The intestinal manifes tations of GVHD. particularly acute GVHD, are the most life-threatening aspects of GVHD, leading to severe mucosal sloughing, watery diarrhea, hemorrhage, and coloniza tion with associated sepsis. Yet GVHD in this organ is still an enigma, with basic ques tions about the pathophysiology of mucosal injury unknown and under current debate. Clearly the small and large intestines can not be simply regarded as target tissues. They arc, in addition, primary lymphoid tissues,
