Endogenous peptides profiles of human infantile hemangioma tissue and their cilinical significant for treatment
Endogenous peptides profiles of human infantile hemangioma tissue and their cilinical significant for treatment
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人婴儿血管瘤组织的内源性肽谱及其临床治疗意义
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Jun Li
中科院分区：
文献类型：
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作者：
Qian Li;Jingyun Li;Ling Chen;Jun Li
内源性肽在多种生物过程中发挥着重要作用。他们的影响。人类婴幼儿血管瘤的发病机制尚不清楚。在这。研究中，我们构建了人类婴儿之间的比较肽组谱。用液相色谱-串联质谱法测定血管瘤组织和匹配的正常皮肤。共有192个肽在人体内有显著差异表达。婴儿血管瘤组织中182个多肽上调，10个多肽下调。在婴儿血管瘤组织和匹配的正常皮肤之间。执行。生物信息学分析（基因本体和京都基因与基因组百科全书）。途径分析)，我们发现这些前体蛋白存在差异表达。多肽具有代谢过程、生物调控、结合、催化等功能。婴儿血管瘤病理变化过程中发生的肿瘤活动和途径。此外，89个差异表达肽与。抗菌肽和13个匹配的已知免疫调节肽基于。预测数据库。总之，我们的结果显示了显著的表达改变。人婴儿血管瘤组织中多肽的谱图。这些peptidesmayparticipate。探讨婴幼儿血管瘤的病因，为临床治疗提供有益的方案。
Endogenous peptides play crucial roles in various biological processes. Their effects on.the pathogenesis of human infantile hemangioma remains poorly understood. In this.study, we construct a comparative peptidomic profiling between human infantile.hemangioma tissue and matched normal skin using liquid chromatography-tandemmass.spectrometry.Atotal of 192 peptides were significantly differentially expressed in human.infantile hemangioma tissue, with 182 upregulated, and 10 downregulated peptides.between infantile hemangioma tissue and matched normal skin. Performing.bioinformatics analysis (Gene ontology andKyoto Encyclopedia ofGenes andGenomes.pathway analysis), we found that precursor proteins of these differentially expressed.peptides correlate with metabolic process, biological regulation, binding, catalytic.activity, and pathways in cancer occurring during pathological changes of infantile.hemangioma. Furthermore, 89 differentially expressed peptides shared homology with.antimicrobial peptides and 13 matched known immunomodulatory peptides based on.prediction database. In conclusion, our results reveal significantly altered expression.profiles of peptides inhumaninfantile hemangioma tissue. These peptidesmayparticipate.in the etiology of infantile hemangioma and provide beneficial scheme for clinical.treatments.