Reproductive effort decreases antibody responsiveness
Reproductive effort decreases antibody responsiveness
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DOI：
10.1098/rspb.1997.0141
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发表时间：
1997-07-22
影响因子：
4.7
通讯作者：
Bos, N
中科院分区：
文献类型：
--
作者：
Deerenberg, C;Arpanius, V;Bos, N
动物在繁殖时寄生虫感染的流行率和强度通常会增加。这可能是由于繁殖努力导致寄生虫传播率增加的结果。另外，与生殖相关的内分泌变化也可能导致免疫抑制。在这里，我们为第三种潜在机制提供了支持：在能量需求增加时，由于资源的适应性重新分配而导致免疫能力降低。在圈养斑胸草雀 Taeniopygia guttata 中，繁殖努力是通过巢的大小来控制的。研究发现，加强努力会影响绵羊红细胞抗体的产生。此外，斑胸草雀的活动不受父母照顾的影响。通过实验增加活动奖励计划中的每日工作量也抑制了抗体的产生。因此，我们表明，不仅生殖状态，而且伴随生殖的活动增加也与免疫能力相关。这种机制可能足以解释在繁殖动物中观察到的寄生现象的增加。我们认为，由于繁殖努力增加而导致的免疫能力降低可能是繁殖生命史成本的重要途径。
The prevalence and intensity of parasitic infection often increases in animals when they are reproducing. This may be a consequence of increased rates of parasite transmission due to reproductive effort. Alternatively, endocrine changes associated with reproduction can lead to immunosuppression. Here we provide support for a third potential mechanism: reduced immunocompetence as a consequence of adaptive reallocation of resources in times of increased energetic demand. In captive zebra finches Taeniopygia guttata, reproductive effort was manipulated through brood size. Enhanced effort was found to affect the production of antibodies towards sheep red blood cells. In addition, activity of zebra finches was manipulated independently of parental care. Experimentally increased daily workloads in activity reward schedules also suppressed antibody production. Thus, we show that not just the reproductive state, but the increased activity that accompanies reproduction is associated With immunocompetence. This mechanism may be sufficient to explain the increased parasitism observed in reproducing animals. We suggest that reduced immunocompetence as a consequence of increased reproductive effort may be an important pathway for the life history cost of reproduction.