Influence of Atrial Fibrillation on Outcomes in Patients Who Underwent Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction
Influence of Atrial Fibrillation on Outcomes in Patients Who Underwent Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction
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DOI：
10.1016/j.amjcard.2017.12.003
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发表时间：
2018-03-15
影响因子：
2.8
通讯作者：
Cox, David
中科院分区：
文献类型：
--
作者：
Garg, Lohit;Agrawal, Sahil;Cox, David
房颤（AF）是急性ST段抬高型心肌梗死（STEMI）患者的常见合并症。此前，小型研究报告了STEAK患者中AF与不良结局之间的相关性。我们进行了这项研究，以使用大型国家数据库研究AF对接受直接经皮冠状动脉介入治疗（PPCI）的STEMI患者的院内结局的影响。研究人群由18岁及以上的患者组成，出院时主要诊断为STEMI并接受PPCI。使用2：1匹配方案，开发了AF患者（N = 24，680）和非AF患者（N = 49，198）的匹配组。在1，493，859例接受PPCI的STEMI患者中，129，354例（8.7%）患者发生AF。在倾向匹配队列中，AF患者的校正院内死亡率显著高于无AF患者（10.3% vs 9.4%）（校正比值比[OR] 1.10;置信区间[CI] 1.06至1.16; p
Atrial fibrillation (AF) is a common co-morbidity among patients presenting with acute ST-segment elevation myocardial infarction (STEMI). Previously, small studies have reported an association between AF and poorer outcomes among patients with STEAK We performed this study to investigate the impact of AF on in-hospital outcomes in patients with STEMI treated with primary percutaneous coronary intervention (PPCI) using a large national database. The study population constituted of patients 18 years and older with a primary discharge diagnosis of STEMI and who underwent PPCI. Using a 2:1 matching protocol, matched groups of patients with AF (N = 24,680) and without (N = 49,198) were developed. Among 1,493,859 patients with STEMI who underwent PPCI, 129,354 patients (8.7%) had AF. In the propensity-matched cohort, adjusted in-hospital mortality was significantly higher for patients with AF compared with patients with no AF (10.3% vs 9.4%) (adjusted odds ratio [OR] 1.10; confidence interval [CI] 1.06 to 1.16; p