Uterine Receptivity is Reflected by LIF Expression in the Cervix
Uterine Receptivity is Reflected by LIF Expression in the Cervix
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DOI：
10.1007/s43032-021-00816-8
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发表时间：
2021-12-02
影响因子：
2.9
通讯作者：
Osuga, Yutaka
中科院分区：
文献类型：
--
作者：
Fukui, Yamato;Hirota, Yasushi;Osuga, Yutaka
复发性着床失败是辅助生殖技术（ART）中的一个主要问题。尽管ART系统在过去几十年中发展迅速，但在不使用侵入性子宫内膜手术的情况下，仍然难以诊断适合胚胎移植（ET）的子宫状况。先前在小鼠中的研究表明，白血病抑制因子（LIF）是一种众所周知的子宫内膜生物标志物，用于子宫着床能力，也称为子宫容受性。这项研究集中在小鼠和人类宫颈中的LIF作为着床能力的可能生物标志物。我们发现LIF在小鼠围着床期宫颈上皮和子宫上皮的高表达密切相关。同样地，人宫颈上皮在围着床期也表现出LIF水平升高。此外，在具有由药物治疗引起的植入缺陷的小鼠中，宫颈LIF下调。这些结果表明，宫颈LIF是一个可能的生物标志物，检测子宫容受性无浸润性子宫内膜损伤。
Recurrent implantation failure is a major problem in assisted reproductive technology (ART). Although ART systems have evolved rapidly over the decades, it is still difficult to diagnose uterine conditions suitable for embryo transfer (ET) without the use of invasive endometrial procedures. Previous studies in mice showed that leukemia inhibitory factor (LIF) is a well-known endometrial biomarker for uterine implantation capacity, also known as uterine receptivity. This study focused on LIF in the mouse and human cervix as a possible biomarker of implantation capacity. We found that high expression of LIF in the cervical epithelium is strongly correlated with that of the uterine epithelium during the peri-implantation period in mice. Likewise, human cervical epithelia also exhibit elevated levels of LIF in the peri-implantation period. In addition, cervical LIF is downregulated in mice with defective implantation caused by pharmacological treatments. These results indicated that cervical LIF is a possible biomarker that detected uterine receptivity without invasive endometrial damage.