MOF-derived nano-popcorns synthesized by sonochemistry as efficient sensitizers for tumor microwave thermal therapy
MOF-derived nano-popcorns synthesized by sonochemistry as efficient sensitizers for tumor microwave thermal therapy
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通过声化学合成的 MOF 衍生的纳米爆米花作为肿瘤微波热疗的有效敏化剂
DOI：
10.1016/j.biomaterials.2020.119773
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发表时间：
2020-03-01
期刊：
影响因子：
14
通讯作者：
Meng, Xianwei
中科院分区：
文献类型：
--
作者：
Li, Ting;Wu, Qiong;Meng, Xianwei
与传统的肿瘤治疗方法相比，微波热疗具有更好的治疗效果和更小的副作用，近年来得到了蓬勃发展。为了促进微波辐射下肿瘤细胞的凋亡，达到更好的治疗效果和预后，各种微波增敏剂应运而生。金属有机骨架(MOF)因其形态多样、表面多孔性和良好的生物降解性而成为最受欢迎的微波敏化材料之一。然而，制备条件苛刻、生长时间长是MOF难以克服的缺点。此外，MOF的海绵状多孔结构不利于离子的滞留，导致在微波辐射下离子间的摩擦和碰撞不足。在本论文中，我们采用快速声化学气溶胶流动法制备了一种尺寸约为250 nm的张口型纳米爆米花(ZDNP)。与UIO.66相比，张口型ZDNPs由于其表面的大裂缝，具有更好的捕获更多离子的能力，从而提高了其微波敏化性能。体外微波加热实验表明，在相同浓度下，ZDNP的净温度变化值比UIO-66高120%，证明ZDNP具有比UIO-66更高的微波热转换效率，这为探索更多样化的微波增敏剂提供了前所未有的方向。
Microwave (MW) thermal therapy has been vigorously developed in recent years because of its better therapeutic efficiency and smaller side effects compared with traditional tumor treatment methods. In order to promote the tumor cell apoptosis under MW irradiation and achieve better therapeutic effect and prognosis, various microwave sensitizers have been developed. Metal organic frameworks (MOFs) have become one of the most popular materials for microwave sensitization due to their diverse morphology, porous surface and good biodegradability. However, the harsh preparation conditions and long growth time are insurmountable shortcomings of MOFs. Besides, the spongy porous structure of MOFs is not conducive to the retention of ions, leading to insufficient friction and collision between ions under MW radiation. Herein, we synthesized a kind of openmouthed Zr MOP-derived nano-popcorns (ZDNPs) with the size of about 250 nm by a rapid sonochemical aerosol flow strategy. Compared with UIO.66, the open-mouthed ZDNPs have a better ability to entrap more ions due to their big cracks on the surface, thus improving their MW sensitization performance. The MW heating experiments in vitro present that the net temperature change value of ZDNP was 120% higher than UIO.66 at the same concentration, proving that ZDNP had a higher MW-thermo conversion efficiency than UIO-66, which provided an unprecedented direction for the exploration of more diversified MW sensitizers.