Astaxanthin alleviates brain aging in rats by attenuating oxidative stress and increasing BDNF levels
Astaxanthin alleviates brain aging in rats by attenuating oxidative stress and increasing BDNF levels
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DOI：
10.1039/c3fo60400d
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发表时间：
2014-01-01
期刊：
影响因子：
6.1
通讯作者：
Liu, Xuebo
中科院分区：
文献类型：
--
作者：
Wu, Wanqiang;Wang, Xin;Liu, Xuebo
虾青素（AST）是一种类胡萝卜素色素，具有有效的抗氧化、抗炎和神经保护作用。本研究旨在探讨AST对D-半乳糖诱导的大鼠脑老化是否具有保护作用，并进一步探讨其保护机制。结果表明，AST能显著恢复衰老大鼠脑组织中谷胱甘肽过氧化物酶（GSH-PX）和超氧化物歧化酶（SOD）的活性，提高谷胱甘肽（GSH）含量和总抗氧化能力（T-AOC），降低丙二醛（MDA）、蛋白质羰基化和8-羟基脱氧鸟苷（8-OHdG）含量。AST可增加衰老大鼠脑组织Bcl-2/Bax比值，降低环氧合酶-2（考克斯-2）的表达。此外，AST改善海马的组织病理学变化，并恢复脑源性神经营养因子（BDNF）在大脑和海马的衰老大鼠的水平。这些结果表明AST可以减轻脑衰老，这可能是由于减轻氧化应激、改善海马损伤和上调脑源性神经营养因子表达。
Astaxanthin (AST) is a carotenoid pigment which possesses potent antioxidative, anti-inflammatory, and neuroprotective properties. The aim of this study was to investigate whether administration of AST had protective effects on D-galactose-induced brain aging in rats, and further examined its protective mechanisms. The results showed that AST treatment significantly restored the activities of glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD), and increased glutathione (GSH) contents and total antioxidant capacity (T-AOC), but decreased malondialdehyde (MDA), protein carbonylation and 8-hydroxy-2- deoxyguanosine (8-OHdG) levels in the brains of aging rats. Furthermore, AST increased the ratio of Bcl-2/Bax, but decreased the expression of Cyclooxygenase-2 (COX-2) in the brains of aging rats. Additionally, AST ameliorated histopathological changes in the hippocampus and restored brain derived neurotrophic factor (BDNF) levels in both the brains and hippocampus of aging rats. These results suggested that AST could alleviate brain aging, which may be due to attenuating oxidative stress, ameliorating hippocampus damage, and upregulating BDNF expression.