Kosen-cha, a Polymerized Catechin-Rich Green Tea, as a Potential Functional Beverage for the Reduction of Body Weight and Cardiovascular Risk Factors: A Pilot Study in Obese Patients
Kosen-cha, a Polymerized Catechin-Rich Green Tea, as a Potential Functional Beverage for the Reduction of Body Weight and Cardiovascular Risk Factors: A Pilot Study in Obese Patients
复制标题
DOI：
10.1248/bpb.b19-00921
复制
发表时间：
2020-04-01
影响因子：
2
通讯作者：
Morimoto, Tatsuya
中科院分区：
文献类型：
--
作者：
Katanasaka, Yasufumi;Miyazaki, Yusuke;Morimoto, Tatsuya
以前的研究表明，绿色茶儿茶素（GTC）对肥胖和代谢综合征有有益的影响。在这项研究中，我们使用高压萃取从绿色茶中制备广宣茶，以减少绿色茶的涩味。我们在kosen-cha中发现了大量的聚合GTC。为了研究含有聚合GTC的kosen-cha在肥胖日本患者中的作用，我们设计了一项开放标签的初步研究，其中6名肥胖受试者（体重指数（BMI）>25 kg/m2）服用kosen-cha（5 g/L/d）12周。在给药前和给药后12周，测量身体成分、血脂、胰岛素抵抗、血管功能和心肌肥厚。Kosen-cha对患者没有明显的不良影响。给药12周后，体重、BMI、腰围、血清甘油三酯（TG）水平和作为胰岛素抵抗指标的稳态模型评估（HOMA-IR）水平显著降低。血流介导的舒张功能（FM D）（p = 0.0214）、臂踝脉搏波速度（baPWV）（p = 0.0141）、左心室质量指数（p = 0.0120）和血浆脑钠肽（BNP）（p = 0.0144）显著改善。总的来说，康生茶可以减少肥胖，改善胰岛素抵抗、血管功能和心脏肥大，这表明它在肥胖和代谢综合征方面具有预防潜力。
Previous studies have shown that green tea catechins (GTCs) have beneficial effects on obesity and metabolic syndromes. In this study, we prepared kosen-cha from green tea using high pressure extraction, to reduce the astringent taste of the green tea. We identified a large quantity of polymerized GTCs in kosen-cha. To investigate the effects of kosen-cha containing polymerized GTCs in obese Japanese patients, we designed an open-label pilot study in which 6 obese subjects (body mass index (BMI) >25 kg/m(2)) were administered kosen-cha (5 g/L/d) for 12 weeks. Body composition, serum lipids, insulin resistance, vascular functions, and cardiac hypertrophy were measured before and 12 weeks after kosen-cha administration. Kosen-cha showed no significant adverse effects on the patients. Body weights, BMI, waist circumferences, serum triglyceride (TG) levels, and homeostasis model assessment as an index of insulin resistance (HOMA-IR) levels were significantly decreased after the 12 weeks of administration. Flow-mediated dilation (FM D) (p = 0.0214), brachial-ankle pulse wave velocity (baPWV)(p = 0.0141), left ventricular mass indexes (p = 0.0120), and plasma brain natriuretic peptide (BNP) (p = 0.0144) were significantly improved. Overall, kosen-cha reduced obesity and improved insulin resistance, vascular function, and cardiac hypertrophy, indicating its preventive potential in obesity and metabolic syndrome.