Access of reproductive steroids to target tissues
Access of reproductive steroids to target tissues
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DOI：
10.1016/s0889-8545(02)00008-6
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发表时间：
2002-09-01
影响因子：
3.2
通讯作者：
Hammond, GL
中科院分区：
文献类型：
--
作者：
Hammond, GL
天然和合成类固醇对它们的靶细胞的进入受到组织特异性的解剖学、生理学和生物化学变量的影响，并且在许多情况下还受到生理状态的影响。它们包括血管供应的差异，靶细胞相对于血管的解剖位置，靶细胞所在组织的细胞和细胞外基质组成，以及类固醇与其血浆转运蛋白之间的相互作用。在设计或评价涉及天然或合成类固醇的治疗时，这些变量往往被忽视，这些类固醇越来越多地被年轻妇女用作避孕药或用于老年人的激素替代品。本文探讨了这些问题，特别强调血浆类固醇结合蛋白在调节影响女性生殖组织的类固醇代谢和作用中的作用。
The access of natural and synthetic steroids to their target cells is influenced by anatomic, physiologic, and biochemical variables that are tissue-specific and in many instances is also influenced by physiologic state. They include differences in vascular supply, the anatomic position of target cells relative to blood vessels, the cellular and extracellular matrix composition of tissues in which target cells are located, and the interaction between steroids and their plasma transport proteins. These variables are often overlooked in the design or evaluation of treatments involving natural or synthetic steroids, which are being used increasingly as contraceptives by young women or for hormonal replacement in the elderly. This article examines these issues with special emphasis on the role that plasma steroid-binding proteins play in regulating the metabolism and actions of steroids that influence reproductive tissues in women.