Nonlocal Effect on Stiffness Measurements of a Collagen Molecule.
Nonlocal Effect on Stiffness Measurements of a Collagen Molecule.
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对胶原分子刚度测量的非局部影响。
DOI：
10.1115/1.4029607
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Birman,Victor
中科院分区：
文献类型：
--
作者：
Birman,Victor
胶原蛋白分子的精确建模，包括其刚度是必不可少的，我们的胶原蛋白纤维和组织的力学的理解，这些纤维发挥了突出的作用。采用各种实验方法和分子动力学（MD）模拟的胶原分子的机械性能的研究产生了广泛的弹性模量值。在这个简短的非局部弹性的分子刚度来自实验和模拟的效果进行评估。考虑非局部效应的修正估计利用一维弹性杆的非局部弹性理论的精确解。结果表明，非局部弹性对胶原分子刚度的影响可以忽略不计。
Accurate modeling of collagen molecules including their stiffness is essential for our understanding of mechanics of collagen fibers and tissues where these fibers play a prominent role. Studies of mechanical properties of collagen molecules employing various experimental methods and molecular dynamics (MD) simulations yield a broad range of values of the modulus of elasticity. The effect of nonlocal elasticity on the molecule stiffness derived from experiments and simulations is assessed in this brief. The estimate of the correction accounting for the nonlocal effect utilizes the exact solution of the nonlocal elasticity theory for one-dimensional elastic bars. It is demonstrated that the effect of nonlocal elasticity on the stiffness of collagen molecules can be neglected.