VOLUMES OF DISTRIBUTION AND CLEARANCES OF INTRAVENOUSLY INJECTED CREATININE IN THE DOG
VOLUMES OF DISTRIBUTION AND CLEARANCES OF INTRAVENOUSLY INJECTED CREATININE IN THE DOG
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DOI：
10.1152/ajplegacy.1955.181.2.330
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发表时间：
1955-01-01
影响因子：
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通讯作者：
HANUSEK, G
中科院分区：
文献类型：
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作者：
SAPIRSTEIN, LA;VIDT, DG;HANUSEK, G
推导了用于分析两室系统中注入物质消失曲线的方程，其中一室以与其现有浓度成正比的速率将注入物质排除到外部，并以与第一和第二室之间的现有浓度差成比例的速率将其转移到第二室。由这些方程预测的消失曲线为双指数曲线。给出了将这种双指数曲线的截距和斜率换算为排泄物间隙和室间间隙以及第一和第二分配体积的公式。在狗的10个实验中，有9个实验的肌酐消失曲线符合双指数过程。由肌酐消失曲线计算的肌酐清除量与同时测定的甘露醇清除量符合较好。肌酐快速分布的体积大致对应于甘露醇空间(细胞外液)，但可能并不总是产生真实解剖空间的有效测量。室间隙为100~359毫升/分钟。肌酐分布的总体积是体重的36.8%，这个数字比以前报道的任何一个数字都要小得多。文中还讨论了产生差异的原因。
Equations were derived for the analysis of the disappearance curve of an injected material from a 2 compartment system, one compartment of which eliminates the injected material to the outside at a rate proportional to its existing concentration and transfers it to the 2d compartment at a rate proportional to the existing concentration difference between the 1st and 2d compartments. The disappearance curves predicted from these equations are double exponential curves. Formulas are given for converting the intercepts and slopes of such double exponential curves into values for the excretory and intercompartmental clearances and the 1st and 2d volumes of distribution. The disappearance curve of creatinine corresponded to a double exponential process in 9 of 10 experiments in dogs. The creatinine clearance calculated from the creatinine disappearance curve was in good agreement with the mannitol clearance simultaneously determined. The volume of rapid distribution of creatinine corresponded roughly to the mannitol space (extracellular fluid) but may not always yield a valid measure of a true anatomical space. The intercompartmental clearance ranged from 100-359 ml/minute. The total volume of creatinine distribution was 36.8% of the body weight, a figure considerably smaller than any previously reported. Reasons for the discrepancy are discussed.