Reduced serum levels of adiponectin in elderly patients with major depression
Reduced serum levels of adiponectin in elderly patients with major depression
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DOI：
10.1016/j.jpsychires.2012.04.028
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发表时间：
2012-08-01
影响因子：
4.8
通讯作者：
Forlenza, Orestes V.
中科院分区：
文献类型：
--
作者：
Diniz, Breno S.;Teixeira, Antonio L.;Forlenza, Orestes V.
最近的研究表明，脂联素和其他脂肪细胞因子参与脑功能，特别是与记忆和认知相关的过程。原发性认知障碍患者，如阿尔茨海默病和轻度认知障碍，以及成年重度抑郁症患者的脂联素血液水平降低。本研究的目的是确定与健康老年人相比，老年抑郁症（MOD）患者的血清脂联素水平，并检查脂联素水平和情绪和认知状态的指标之间的相关性。在这项研究中，我们招募了51名未经药物治疗的老年抑郁症（LLD）门诊患者和47名年龄匹配的对照组。根据DSM-IV标准诊断抑郁症，并采用21项汉密尔顿抑郁量表（HORS）确定抑郁发作的严重程度。采用剑桥认知测验（CAMCOG）和简易精神状态检查（MMSE）确定认知状态。采用夹心ELISA法测定血清脂联素浓度。LLD患者血清脂联素水平显著降低（F = p < 0.001）。在控制BMI指数、CAMCOG、MMSE、HDRS评分和文化程度后，脂联素水平仍显著降低（P < 0.001）。脂联素水平与HORS评分（r =-0.59，p < 0.001）、BMI指数（r =-0.42，p < 0.001）呈负相关，与CAMCOG评分（r = 0.34，p < 0.01）、MMSE评分（r = 0.20，p = 0.05）呈正相关。老年抑郁症患者循环脂联素的可用性降低，可能影响认知和情绪状态。需要进一步的研究来确定这种异常是否与老年抑郁症本身的病理生理学有关，或者是病态的结果。(C)2012爱思唯尔有限公司保留所有权利。
Recent studies have implicated adiponectin and other adipocytokines in brain function, particularly in processes related to memory and cognition. Blood levels of adiponectin are reduced in patients with primary cognitive disorders, such as Alzheimer's disease and mild cognitive impairment, and in adult patients with major depression. The aim of the present study is to determine serum levels of adiponectin in a sample of elderly patients with major depressive disorder (MOD) as compared to healthy older adults, and to examine the correlations between adiponectin levels and parameters indicative of mood and cognitive state. We recruited fifty-one unmedicated outpatients with late-life depression (LLD) and 47 age-matched controls in this study. The diagnosis of MDD was made according to the DSM-IV criteria, and the severity of depressive episode was determined with the 21-item Hamilton Depression Scale (HORS). Cognitive state was ascertained with the Cambridge Cognitive Test (CAMCOG) and the Mini-Mental State Examination (MMSE). Serum concentrations of adiponectin were determined using a sandwich ELISA method. Serum levels of adiponectin were significantly reduced in individuals with LLD (F = p < 0.001). Adiponectin level remained significantly reduced in after controlling for BMI index, scores on the CAMCOG, MMSE and HDRS and educational level (p < 0.001). Adiponectin levels showed a negative correlation with HORS scores (r = -0.59, p < 0.001) and BMI index (r = -0.42, p < 0.001); and showed a positive correlation with CAMCOG (r = 0.34, p < 0.01) and MMSE scores (r = 0.20, p = 0.05). The availability of circulating adiponectin is reduced in older adults with major depression, with likely implications on cognitive and mood state. Additional studies are required to determine whether this abnormality pertains to the pathophysiology of geriatric depression per se, or is a consequence of the morbid state. (C) 2012 Elsevier Ltd. All rights reserved.