High temperature zincation of functionalized aromatics and heteroaromatics using TMPZnCl.LiCl and microwave irradiation.
High temperature zincation of functionalized aromatics and heteroaromatics using TMPZnCl.LiCl and microwave irradiation.
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DOI：
10.1039/b913693b
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发表时间：
2009-09
影响因子：
4.9
通讯作者：
M. Mosrin;Gabriel Monzón;Tomke Bresser;P. Knochel
中科院分区：
文献类型：
--
作者：
M. Mosrin;Gabriel Monzón;Tomke Bresser;P. Knochel
采用TMPZnCl、LiCl和微波辐射，通过区域选择性和化学选择性锌化反应，有效地合成了一系列芳基和杂芳基锌试剂。酯等敏感官能团与反应的高温相容。所得的锌物质经历许多后续反应，以高产率提供高度官能化的芳香族化合物和杂芳香族化合物。
A wide range of functional aryl and heteroaryl zinc reagents have been efficiently prepared via regio- and chemoselective zincation using TMPZnCl.LiCl and microwave irradiation. Sensitive functional groups like esters are compatible with the high temperatures of the reactions. The resulting zinc species undergo a number of subsequent reactions, providing highly functionalized aromatics and heteroaromatics in high yields.