The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity.
The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity.
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发表时间：
1995
影响因子：
4.4
通讯作者：
R. Klein;Qin Wang;B. Klein;S. Moss;S. Meuer
中科院分区：
文献类型：
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作者：
R. Klein;Qin Wang;B. Klein;S. Moss;S. Meuer
目的 在基于人群的 Beaver Dam 眼科研究中探讨年龄相关性黄斑病、白内障和青光眼与视力的关系。方法 对居住在威斯康星州 Beaver Dam 的 43 至 86 岁人群进行了一项横断面、以人群为基础的研究，这些人于 1987 年至 1988 年间被识别，并于 1988 年至 1990 年间接受了检查（n = 4926）。在参与者中，99.4% 是白人。使用早期治疗糖尿病视网膜病变研究方案的修订版测量了视力（n = 4886）。使用标准化方案对立体彩色眼底照片、裂隙灯和晶状体逆照照片进行分级，以确定年龄相关性黄斑病变和中心性白内障的存在。结果 57% 的法定盲人双眼患有晚期年龄相关性黄斑病变。渗出性黄斑变性眼 (48%) 的视力为 20/200 或更差的频率与单纯地理性萎缩眼 (42%) 没有显着差异。在控制其他因素（年龄、中心性白内障和青光眼）的同时，患有可分级年龄相关性黄斑病且至少一只眼睛可测量视力的参与者（n = 4716）中，研究人员发现，与没有这些病变的眼睛相比，每一种早期年龄相关性黄斑病病变都与视力下降约两个字母或更少有关。晚期年龄相关性黄斑病变与正确阅读的字母减少约七行有关。结论 这些数据表明，渗出性黄斑变性和纯粹地理性萎缩是该人群法定失明的最重要原因，而早期年龄相关性黄斑病、中心性白内障和青光眼对视力影响较小。
PURPOSE To investigate the relationship of age-related maculopathy, cataract, and glaucoma to visual acuity in the population-based Beaver Dam Eye Study. METHODS A cross-sectional, population-based study was performed in people 43 through 86 years of age residing in Beaver Dam, Wisconsin, who were identified between 1987 and 1988 and examined (n = 4926) between 1988 and 1990. Of those who participated, 99.4% were white. Visual acuity was measured (n = 4886) using a modification of the Early Treatment Diabetic Retinopathy Study protocol. Stereoscopic color fundus photographs and slit lamp and retroillumination photographs of the lens were graded in a masked fashion using standardized protocols to determine the presence of age-related maculopathy and central cataract. RESULTS Fifty-seven percent of those who were legally blind had late age-related maculopathy in both eyes. The frequency of visual acuity of 20/200 or worse was not significantly different in eyes with exudative macular degeneration (48%) than in eyes with pure geographic atrophy (42%). While controlling for other factors (age, central cataract, and glaucoma) in participants with both gradable age-related maculopathy and visual acuity measurable in at least one eye (n = 4716), investigators found that each of the early age-related maculopathy lesions was associated with a decrease in visual acuity of approximately two letters or fewer when compared to eyes without these lesions. Late age-related maculopathy was associated with a decrease of approximately seven lines of letters read correctly. CONCLUSION These data demonstrate that exudative macular degeneration and pure geographic atrophy are the most important causes of legal blindness in this population and that early age-related maculopathy, central cataract, and glaucoma had a small effect on visual acuity.