Clinical aspects of 2541 patients with second stage human African trypanosomiasis
Clinical aspects of 2541 patients with second stage human African trypanosomiasis
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DOI：
10.1016/j.actatropica.2005.08.001
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发表时间：
2006-01-01
期刊：
影响因子：
2.7
通讯作者：
Burri, C
中科院分区：
文献类型：
--
作者：
Blum, J;Schmid, C;Burri, C
描述了一项前瞻性多中心、多国研究中接受治疗的大型患者队列中第二期HAT患者的临床症状和体征。特别强调疾病阶段（持续时间，CSF中WBC数量）和患者年龄对临床表现的影响。尽管各中心之间症状和体征的频率差异很大，但所有国家的疾病临床情况相似。头痛（78.7%）、睡眠障碍（74.4%）和淋巴结肿大（56.1%）是最常见的症状和体征，并且在疾病的各个阶段都是相似的。淋巴结肿大在第二阶段晚期最高（59.0%）。神经和精神症状随着CSF中WBC数量的增加而显著增加，表明疾病的进展阶段。在所有阶段均观察到瘙痒，并且随着CSF中WBC数量从30%增加到55%而增加。在7岁以下儿童中，淋巴结病的报告率（11.8-37.3%）低于年龄较大的儿童或成人（56.4-61.2%）。2至14岁儿童最常报告发烧（26.1-28.7%），所有年龄段儿童（43-56%）的营养不良率明显高于成人（23.5%）。(C)2005 Elsevier B. V.保留所有权利。
The clinical symptoms and signs of patients with second stage HAT are described for a large cohort of patients treated in a prospective multicentre, multinational study. Special emphasis is given to the influence of disease stage (duration, number of WBC in CSF) and patient age to the clinical picture. Even though the frequencies of symptoms and signs are highly variable between centres, the clinical picture of the disease is similar for all countries. Headache (78.7%), sleeping disorder (74.4%) and lymphadenopathy (56.1%) are the most frequent symptoms and signs and they are similar for all stages of the disease. Lymphadenopathy tends to be highest in the advanced second stage (59.0%). The neurological and psychiatric symptoms increase significantly with the number of WBC in the CSF indicating the stage of progression of the disease. Pruritus is observed in all stages and increases with the number of WBC in CSF from 30 to 55%. In children younger than 7 years, lymphadenopathy is less frequently reported (11.8-37.3%) than in older children or adults (56.4-61.2%). Fever is most frequently reported in children between 2 and 14 years of age (26.1-28.7%) and malnutrition is significantly more frequently observed in children of all ages (43-56%) than in adults (23.5%). (C) 2005 Elsevier B.V. All rights reserved.