Ability of eugenol to reduce tongue edema induced by Dieffenbachia picta Schott in mice
Ability of eugenol to reduce tongue edema induced by Dieffenbachia picta Schott in mice
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DOI：
10.1016/j.toxicon.2004.03.005
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发表时间：
2004-05-01
期刊：
影响因子：
2.8
通讯作者：
Fernandes, PD
中科院分区：
文献类型：
--
作者：
Dip, EC;Pereira, NA;Fernandes, PD
花叶万年青（天南星科），在巴西被称为“comigo-ninguem-pode”，是一种具有毒性的观赏植物。它的汁液，当咀嚼时，会引起口腔粘膜的疼痛水肿，颊溃疡和舌头肥大。这种急性炎症有时会严重到足以引起声门阻塞、呼吸系统损害和死亡。丁香酚（4-烯丙基-2-甲基苯酚）是从桃金娘科植物丁香中提取的挥发油，广泛应用于口腔医学。在这项研究中，我们的目的是标准化，在小鼠中，可测量的方法，由局部应用的D。观察丁香酚在该模型中的作用，并与医院急诊治疗的结果进行比较。我们的研究结果表明，尽管在给药后几分钟水肿略有增加，但紧急治疗使总体水肿减少了70%。当与上述药物的组合相比时，丁香酚，即使在5 μ g/kg的最小剂量下，无论选择的给药途径或治疗开始的时刻如何，在减少和抑制由D. picta果汁。(C)2004爱思唯尔有限公司保留所有权利。
Dieffenbachia picta Schott (Araceae), known in Brazil as 'comigo-ninguem-pode' is an ornamental plant with toxic properties. Its juice, when chewed, causes a painful edema of the oral Mucous membranes, buccal ulcerations and tongue hypertrophy. This acute inflammation sometimes becomes severe enough to produce glottis obstruction, respiratory compromise and death. Eugenol (4-alil-2-metoxiphenol), the essential oil extracted from Caryophyllus aromaticus (Myrtaceae) is widely used in odontology. In this study, our objective was to standardize, in mice, a measurable methodology for the tongue edema induced by the topical application of the D. picta stem juice; evaluate the effects of eugenol in this model and compare the results with emergency treatment used in hospitals. Our results show that in spite of a small increase in edema a few minutes after administration, emergency treatment reduced by 70% the overall edema. When compared with the combination of the above drugs, eugenol, even at the smallest dose of 5 mug/kg, regardless of the chosen administration route, or the moment the treatment began, presents better results in the reduction and inhibition of the tongue edema induced by the D. picta juice. (C) 2004 Elsevier Ltd. All rights reserved.