Itchy body: Topographical difference of itch and scratching and C Nerve fibres
Itchy body: Topographical difference of itch and scratching and C Nerve fibres
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DOI：
10.1111/exd.14054
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发表时间：
2019-12-05
影响因子：
3.6
通讯作者：
Yosipovitch, Gil
中科院分区：
文献类型：
--
作者：
Hashimoto, Takashi;Yosipovitch, Gil
痒，也称为瘙痒症，是一种令人不快的感觉，导致渴望抓挠。我们可以在任何位置感觉到痒，从头顶到脚趾。然而，瘙痒强度存在地形差异。瘙痒主要是通过C神经纤维从皮肤传导到中枢神经系统。然而，C纤维的缺失并不一定导致更高的瘙痒强度。有趣的是，C纤维的减少和/或结构变化似乎在瘙痒感觉中起作用。此外，C触觉纤维（CT传入），这是由温和的“情感”触摸激活，似乎与抓挠快感和大脑中的奖励系统，可以参与瘙痒感觉和地形的差异瘙痒。
Itch, also known as pruritus, is an unpleasant sensation that results in an urge to scratch. We can feel itch at any location where itch occurs from the top of the head to the toes. However, there are topographical differences in itch intensity. Itch is mainly conducted by C nerve fibres from the skin where itch emanates to the central nervous system. However, the abundancy of C fibres does not necessarily lead to higher itch intensity. Interestingly, reduction and/or structural changes in C fibres seem to play a role in itch sensation. In addition, C tactile fibres (CT afferents), which are activated by gentle "affective" touch and seem to be associated with scratching pleasurability and the reward system in the brain, can be involved in itch sensation and topographical differences of itch.