Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length.
Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length.
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视交叉上核中的加压素 mRNA：聚腺苷酸尾长的日常调节。
DOI：
10.1126/science.3388044
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Majzoub,JA
中科院分区：
文献类型：
--
作者：
Robinson,BG;Frim,DM;Schwartz,WJ;Majzoub,JA
在哺乳动物视交叉上核中，与加压素信使RNA相连的聚腺苷酸尾的长度每天都有变化，视交叉上核是哺乳动物内源性昼夜节律起搏器的位置。在视上核或室旁核没有发现这种变化。聚腺苷酸尾部长度的这种变化可能是脑脊液中加压素肽水平的昼夜节律的基础，并且是信使RNA结构中每日节律的独特例子。
Daily variation has been found in the length of the polyadenylate tail attached to vasopressin messenger RNA in the suprachiasmatic nuclei, which is the location of an endogenous circadian pacemaker in mammals. No such variation was found in the supraoptic or paraventricular nuclei. This variation in the length of the polyadenylate tail may underlie the circadian rhythm of vasopressin peptide levels in cerebrospinal fluid and is a unique example of a daily rhythm in messenger RNA structure.