Tracking differential activation of primary and supplementary motor cortex across timing tasks: An fNIRS validation study
Tracking differential activation of primary and supplementary motor cortex across timing tasks: An fNIRS validation study
复制标题
DOI：
10.1016/j.jneumeth.2020.108790
复制
发表时间：
2020-07-15
影响因子：
3
通讯作者：
Bortfeld, Heather
中科院分区：
文献类型：
--
作者：
Rahimpour, Ali;Pollonini, Luca;Bortfeld, Heather
功能近红外光谱（fNIRS）提供了一种替代功能磁共振成像（fMRI）评估皮质血流动力学的变化。为了建立实用的fNIRS测量差分招聘的运动网络在生产的时间为基础的行动，我们测量皮质血流动力学反应10名健康成人，而他们进行了两个版本的手指敲击任务。在早期的fMRI研究中使用的任务（Jantzen等人，2004），旨在跟踪不同时间行为的神经基础。参与者将敲击节奏调整到有节奏的音调，然后在没有音调的情况下继续以既定的节奏敲击。最初的敲击是同步的或相对于音调的切分音。这产生了一个2x2的设计：同步或切分敲击和节奏的敲击与或继续没有一个音调。在使用fNIRS监测皮质血流动力学的同时，跟踪敲击时间的准确性。在四种条件下，通过典型统计分析计算试验间的血流动力学反应。任务诱导的大脑激活导致运动皮层内和周围广泛区域的氧合血红蛋白浓度（oxygenated hemoglobin concentration，oxy-Hb）显著增加。总的来说，切分敲击在行为上更难，比同步敲击产生更多的皮层激活。因此，我们观察到oxyHb的显着变化与任务的复杂性直接相关。
Functional near-infrared spectroscopy (fNIRS) provides an alternative to functional magnetic resonance imaging (fMRI) for assessing changes in cortical hemodynamics. To establish the utility of fNIRS for measuring differential recruitment of the motor network during the production of timing-based actions, we measured cortical hemodynamic responses in 10 healthy adults while they performed two versions of a finger-tapping task. The task, used in an earlier fMRI study (Jantzen et al., 2004), was designed to track the neural basis of different timing behaviors. Participants paced their tapping to a metronomic tone, then continued tapping at the established pace without the tone. Initial tapping was either synchronous or syncopated relative to the tone. This produced a 2x2 design: synchronous or syncopated tapping and pacing the tapping with or continuing without a tone. Accuracy of the timing of tapping was tracked while cortical hemodynamics were monitored using fNIRS. Hemodynamic responses were computed by canonical statistical analysis across trials in each of the four conditions. Task-induced brain activation resulted in significant increases in oxygenated hemoglobin concentration (oxy-Hb) in a broad region in and around the motor cortex. Overall, syncopated tapping was harder behaviorally and produced more cortical activation than synchronous tapping. Thus, we observed significant changes in oxyHb in direct relation to the complexity of the task.