The chromosomal 2-N-acetyltransferase of Providencia stuartii: Physiological functions and genetic regulation
The chromosomal 2-N-acetyltransferase of Providencia stuartii: Physiological functions and genetic regulation
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DOI：
10.2741/macinga
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发表时间：
1999-02-01
期刊：
影响因子：
--
通讯作者：
Rather, Philip N.
中科院分区：
文献类型：
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作者：
Macinga, David R.;Rather, Philip N.
已在许多细菌中鉴定出参与氨基糖苷类耐药性的内在染色体乙酰转移酶。在普罗威登斯氏菌中，染色体乙酰转移酶 (AAC(2')-Ia) 已被详细表征。除了乙酰化氨基糖苷类的能力之外，AAC(2')-Ia酶还具有至少一种生理功能，即肽聚糖的乙酰化。这种修饰可能会影响 P. Stuartii 的自溶系统。 aac(2')-Ia 表达的调节极其复杂，涉及至少七个在至少两个途径中起作用的调节基因。这种调节的复杂性表明必须严格控制 aac(2')-Ia 表达以响应不同的环境条件。这大概反映了维持正确的肽聚糖乙酰化水平的重要性。在这篇综述中，我们将总结涉及斯图尔特拟青霉中 aac(2')-Ia 的生理和遗传方面的数据。
Intrinsic chromosomal acetyltransferases involved in aminoglycoside resistance have been identified in a number of bacteria. In Providencia stuartii, a chromosomal acetyltransferase (AAC(2')-Ia) has been characterized in detail. In addition to the ability to acetylate aminoglycosides, the AAC(2')-Ia enzyme has at least one physiological function, which is the acetylation of peptidoglycan. This modification is likely to influence the autolytic system in P. stuartii. The regulation of aac(2')-Ia expression is extremely complex involving at least seven regulatory genes acting in at least two pathways. This complexity in regulation indicates that aac(2')-Ia expression must be tightly controlled in response to different environmental conditions. This presumably reflects the importance of maintaining correct levels of peptidoglycan acetylation. In this review, a summary of data will be presented involving both the physiological and genetic aspects of aac(2')-Ia in P. stuartii.