Deficits in sensory gating in schizophrenic patients and their relatives. Evidence obtained with auditory evoked responses.
Deficits in sensory gating in schizophrenic patients and their relatives. Evidence obtained with auditory evoked responses.
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DOI：
10.1001/archpsyc.1984.01790170081009
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发表时间：
1984-06
影响因子：
--
通讯作者：
C. Siegel;M. Waldo;G. Mizner;L. Adler;R. Freedman
中科院分区：
文献类型：
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作者：
C. Siegel;M. Waldo;G. Mizner;L. Adler;R. Freedman
以听觉诱发反应的P50波为条件测试范式，对15例精神分裂症患者及其一级亲属和正常受试者进行了听觉诱发反应抑制门控缺陷的检测。这一范式通过向受试者呈现成对的刺激来展示抑制；第二个刺激诱发的P50波由于在对第一个刺激的反应中激活的抑制机制而被减少。在正常人中，第二次P50反应的平均波幅降低到不到20%。在精神分裂症患者中，第二反应的平均幅度超过第一反应的85%，这一结果重复了我们之前在精神分裂症中发现的抑制缺陷。大约一半的一级亲属，通常包括至少一位父母，有类似的缺陷。父母中这种缺陷的存在与精神分裂症的家族史有关。有这种缺陷的家庭成员在明尼苏达多相人格问卷的多个量表上的得分也显著高于没有这种缺陷的家庭成员。尽管存在抑制缺陷，但亲属的P50波的其他特征是正常的，与未用药的精神分裂症患者形成对比，后者在波潜伏期和幅度上表现出额外的异常。
A deficit in inhibitory gating of auditory evoked responses was examined in 15 schizophrenic patients, their first-degree relatives, and normal subjects, using a conditioning-testing paradigm with the P50 wave of the auditory evoked response. This paradigm demonstrates inhibition by presenting paired stimuli to the subject; the P50 wave evoked by the second stimulus is reduced because of inhibitory mechanisms activated during the response to the first stimulus. In normal subjects, the mean amplitude of the second P50 response was reduced to less than 20%. In the schizophrenics, the mean amplitude of the second response was more than 85% of the first, a result that replicates our previous finding of a deficit in inhibition in schizophrenia. Approximately half the first-degree relatives, generally including at least one parent, had a similar deficit. Presence of this deficit in the parents was associated with a family history of schizophrenia. Family members with this deficit also had significantly higher scores on several scales of the Minnesota Multiphasic Personality Inventory than did family members without the deficit. Despite the deficit in inhibition, other characteristics of the P50 wave were normal in the relatives, in contrast to unmedicated schizophrenics, who showed additional abnormalities in wave latency and amplitude.