Treatment of experimental canine endotoxin shock with ibuprofen, a cyclooxygenase inhibitor.
Treatment of experimental canine endotoxin shock with ibuprofen, a cyclooxygenase inhibitor.
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用环氧合酶抑制剂布洛芬治疗实验性犬内毒素休克。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
S. Schwartz
中科院分区：
文献类型：
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作者：
P. Almqvist;M. Kuenzig;S. Schwartz
花生四烯酸衍生物血栓素 A2 是一种非常有效的血小板聚集剂，在内毒素休克时会增加。布洛芬可阻断血栓素 A2 的形成，并具有抗血小板和抗白细胞聚集特性。在内毒素休克的狗中评估了布洛芬对肺血小板捕获、血小板和白细胞计数、血小板聚集性、血细胞比容和血压的影响。布洛芬治疗并未改变内毒素休克中血压、白细胞和血小板计数的最初下降。 2小时后，与内毒素对照相比，布洛芬治疗的狗的低血压较少。 2 小时后，布洛芬治疗犬的血小板计数也较高。仅当使用预处理时才观察到白细胞的显着恢复。与内毒素对照相比，布洛芬治疗的狗的肺部血小板捕获显着降低，并且与内毒素注射前给予布洛芬的假狗没有显着差异。这项研究证明了布洛芬不仅可以减少肺部血小板滞留，而且可以避免实验性内毒素休克中的晚期低血压。
The arachidonic acid derivative thromboxane A2, a very potent platelet aggregator, is increased in endotoxin shock. Ibuprofen blocks the formation of thromboxane A2 and has antiplatelet and antileukocyte aggregability properties. The effects of ibuprofen on pulmonary platelet trapping, platelet and leukocyte counts, platelet aggregability, hematocrit, and blood pressure were evaluated in endotoxin-shocked dogs. The initial decrease in blood pressure and in leukocyte and platelet counts seen in endotoxin shock was not altered by ibuprofen treatment. At 2 h the ibuprofen-treated dogs had less hypotension compared to endotoxin control. Platelet counts were also higher in the ibuprofen-treated dogs at 2 h. Significant recovery of leukocytes was seen only when pretreatment was used. Pulmonary platelet trapping was significantly lower in the ibuprofen-treated dogs compared to endotoxin controls and not significantly different from the sham dogs when ibuprofen was given before endotoxin injection. This study demonstrates the efficacy of ibuprofen not only in reducing pulmonary platelet trapping but also in obviating the late hypotension in experimental endotoxin shock.