The roles of histidine kinases in sensing host plant and cell-cell communication signal in a phytopathogenic bacterium
The roles of histidine kinases in sensing host plant and cell-cell communication signal in a phytopathogenic bacterium
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组氨酸激酶在植物病原菌中感知宿主植物和细胞间通讯信号中的作用
DOI：
10.1098/rstb.2018.0311
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发表时间：
2019
影响因子：
6.3
通讯作者：
Qian Wei
中科院分区：
文献类型：
--
作者：
Wang Fang Fang;Qian Wei
植物病原细菌对植物特异性刺激或环境因素有反应，这一点早已为人们所知。然而，细菌细胞如何感知这些环境信号仍然没有完全研究。最近，三种组氨酸激酶（HKs）被鉴定为感受植物相关或群体感应信号的受体。在这些激酶中，HK VgrS通过ExxE基序与三价铁结合来检测铁的消耗，RpfC通过其N-末端肽与扩散信号因子（DSF）结合并通过松弛自抑制来激活其自激酶活性，PcrK特异性地感测植物细胞分裂素并激发细菌对氧化应激的反应。这些HK是调节革兰氏阴性细菌Xanthomonascampestrispv. campestris毒力的关键传感器。植物病原细菌HKs信号感知的研究进展显示，寄主植物与病原菌之间的界间信号传导控制致病机制，并可作为潜在的分子靶点，以保护植物免受细菌性疾病的侵害。本文为“生物信号传导揭示智能害虫管理”专题的一部分。
It has long been known that phytopathogenic bacteria react to plant-specific stimuli or environmental factors. However, how bacterial cells sense these environmental cues remains incompletely studied. Recently, three kinds of histidine kinases (HKs) were identified as receptors to perceive plant-associated or quorum-sensing signals. Among these kinases, HK VgrS detects iron depletion by binding to ferric iron via an ExxE motif, RpfC binds diffusible signal factor (DSF) by its N-terminal peptide and activates its autokinase activity through relaxation of autoinhibition, and PcrK specifically senses plant hormone–cytokinin and elicits bacterial responses to oxidative stress. These HKs are critical sensors that regulate the virulence of a Gram-negative bacterium,Xanthomonas campestrispv.campestris. Research progress on the signal perception of phytopathogenic bacterial HKs suggests that inter-kingdom signalling between host plants and pathogens controls pathogenesis and can be used as a potential molecular target to protect plants from bacterial diseases.This article is part of the theme issue ‘Biotic signalling sheds light on smart pest management’.