SINGLE UNIT ANALYSIS OF THE HUMAN VENTRAL THALAMIC NUCLEAR GROUP - ACTIVITY CORRELATED WITH MOVEMENT
SINGLE UNIT ANALYSIS OF THE HUMAN VENTRAL THALAMIC NUCLEAR GROUP - ACTIVITY CORRELATED WITH MOVEMENT
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DOI：
10.1093/brain/113.6.1795
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发表时间：
1990-12-01
期刊：
影响因子：
14.5
通讯作者：
LENZ, YE
中科院分区：
文献类型：
--
作者：
LENZ, FA;KWAN, HC;LENZ, YE
在缓解运动障碍的神经外科手术中，单个丘脑神经元（n = 107）被确定为与口头暗示的主动运动（运动相关细胞）相关的活动。在不同的对侧运动中，每个神经元的活动被检查，以确定哪种运动与最一致和最明显的放电率变化（最佳反应）有关。通过分析神经元活动的直方图来确定最佳反应，该直方图是通过使用肌电图活动的开始来同步连续重复的活跃运动来构建的。与运动相关的细胞表现出最佳的反应，这些反应与握拳、手腕弯曲的延伸、肘部弯曲或伸展、整个上肢指向、伸出舌头和抬起腿等运动有关。在单个患者的单个副矢状面中记录的大多数运动相关细胞对涉及身体同一部位的运动有最佳反应。运动相关细胞分为响应体感觉刺激而激活的细胞（组合细胞，n = 20）和不响应体感觉刺激的细胞（自愿细胞，n = 87）。在主动运动时，联合细胞在肌电图活动之前被激活，并且可以与仅对感觉刺激做出反应的细胞（感觉细胞）区分开来。运动相关细胞（组合细胞和自愿细胞类型）位于感觉细胞的前部，并倾向于显示与具有皮肤感受野的感觉细胞平行的中外侧体位组织。组合细胞对身体同一部位的体感刺激做出反应，就像参与与细胞最佳反应相关的主动运动一样。对关节的被动运动作出反应的组合细胞在同一关节的主动运动中总是有最佳反应。联合细胞在帕金森震颤中的活动可能阐明感觉反馈在震颤中的作用。
During neurosurgical operations for the relief of movement disorders, single thalamic neurons (n = 107) were identified with activity which was related to verbally cued active movements (movement-related cells). The activity of each neuron was examined during different contralateral movements in order to determine the movement which was associated with the most consistent and pronounced change in firing rate (the optimal response). The optimal response was determined by analysis of histograms of neuronal activity which were constructed by using the onset of EMG activity to synchronize successive repetitions of the active movement.Movement-related cells exhibited optimal responses associated with such movement as making a fist, extension of flexion of the wrist, flexing or extending the elbow, pointing with the entire upper extremity, extending the tongue and lifting the leg. Most movement-related cells recorded in a single parasagittal plane in an individual patient had optimal responses related to movements involving the same part of the body. Movement-related cells were classified into those that were activated in response to somatosensory stimulation (combined cells, n = 20) and those which were not (voluntary cells, n = 87). Combined cells were activated in advance of EMG activity during active movement and could be distinguished from cells responding only to sensory stimulation (sensory cells). Movement-related cells (combined and voluntary cell types) were located anterior to sensory cells and tended to show a mediolateral somatotopic organization parallel to that of sensory cells with cutaneous receptive fields. Combined cells responded to somatosensory stimulation of the same part of the body as that involved in the active movement related to the optimal response of the cell. Combined cells responding to passive movements of a joint always had their optimal response during active movement about the same joint. The activity of combined cells during parkinsonian tremor may clarify the role of sensory feedback in tremor.