Determinants of Corneal Biomechanical Properties in an Adult Chinese Population
Determinants of Corneal Biomechanical Properties in an Adult Chinese Population
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DOI：
10.1016/j.ophtha.2010.12.001
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发表时间：
2011-07-01
期刊：
影响因子：
13.7
通讯作者：
Aung, Tin
中科院分区：
文献类型：
--
作者：
Narayanaswamy, Arun;Chung, Ronald S.;Aung, Tin
目的：研究中国成年人角膜滞后（CH）和角膜阻力因子（CRF）的变化及其与眼部和全身的相关性。设计：基于人群的横断面研究。参与者：我们纳入了1136名来自正在进行的基于人群的研究的中国受试者。方法：在这项基于人群的研究中，所有受试者都接受了标准化的眼部检查，包括角膜曲率测量（角膜曲率半径）、用Goldmann压平眼压计测量的眼内压（IOP）、中央角膜厚度（CCT）和眼轴长度（AL）评估。用眼反应分析仪测量CH和CRF。参与者进行了详细的访谈和实验室调查，包括估计非空腹血糖，糖化血红蛋白，和lipidprofile.Main结果Measures：我们评估CH，CRF，和他们的协会与人口，眼睛，和全身factors.Results：研究对象的平均年龄为55.3 +/- 8.4岁，51.2%是女性。平均CH和CRF分别为10.6 ± 1.5和10.1 ± 1.6 mmHg。女性的平均CH（10.8 vs 10.4 mmHg; P < 0.001）和CRF（10.4 vs 9.8 mmHg; P < 0.001）高于男性。在校正年龄、性别、IOP、CCT、角膜曲率、AL和糖尿病后，CH与年龄呈负相关（β = -0.034; P < 0.001），IOP（β = -0.037; P = 0.01），角膜曲率半径（β = -0.963; P < 0.001），AL与性别（β = 0.308; P <0.001）和CCT（β = -0.020; P < 0.001）呈正相关。CRF与年龄呈负相关（β = -0.023; P < 0.001）和角膜曲率半径（β = -0.771; P < 0.001），且与女性性别呈正相关（β = 0.368; P < 0.001）、IOP（β = 0.134; P < 0.001）和CCT（β = 0.024; P < 0.001）。糖尿病组CH（β = 0.324; P < 0.001）和CRF（β = 0.396; P < 0.002）显著高于非糖尿病组。女性和糖尿病患者有更大的CH和CRF。角膜生物力学特性的滞后和阻力因子的显着影响眼压，CCT，角膜曲率半径，和AL。
Purpose: To investigate variations in corneal hysteresis (CH) and corneal resistance factor (CRF) and their ocular and systemic associations in Chinese adults.Design: Population-based, cross-sectional study.Participants: We included 1136 subjects of Chinese origin from an ongoing population-based study.Methods: All subjects in this population-based study underwent a standardized ocular examination including keratometry (corneal radius of curvature), intraocular pressure (IOP) measurement with Goldmann applanation tonometry, central corneal thickness (CCT), and axial length (AL) assessments. The CH and CRF were measured with the Ocular Response Analyzer. Participants underwent a detailed interview and laboratory investigations that included estimation of nonfasting serum glucose, glycosylated hemoglobin, and lipid profile.Main Outcome Measures: We assessed CH, CRF, and their associations with demographic, ocular, and systemic factors.Results: The mean age of study subjects was 55.3 +/- 8.4 years and 51.2% were females. The mean CH and CRF were 10.6 +/- 1.5 and 10.1 +/- 1.6 mmHg, respectively. Women had higher mean CH (10.8 vs 10.4 mmHg; P < 0.001) and CRF (10.4 vs. 9.8 mmHg; P < 0.001) than men. After adjusting for age, gender, IOP, CCT, keratometry, AL, and diabetes, CH was negatively associated with age (beta = -0.034; P < 0.001), IOP (beta = -0.037; P = 0.01), corneal radius of curvature (beta = -0.963; P < 0.001), and AL (beta = -0.106; P < 0.001); and positively associated with female gender (beta = 0.308; P < 0.001) and CCT (beta = -0.020; P < 0.001). The CRF showed a negative association with age (beta = -0.023; P < 0.001) and corneal radius of curvature (beta = -0.771; P < 0.001), and was positively associated with female gender (beta = 0.368; P < 0.001), IOP (beta = 0.134; P < 0.001) and CCT (beta = 0.024; P < 0.001). Subjects with diabetes had a higher CH (beta = 0.324; P < 0.001) and CRF (beta = 0.396; P < 0.002) compared with those without diabetes.Conclusions: With advancing age, the CH and CRF in adult Chinese decreased. Women and subjects with diabetes had greater CH and CRF. Corneal biomechanical properties of hysteresis and resistance factor are significantly influenced by IOP, CCT, corneal radius of curvature, and AL.