Geographic distribution and epidemiology of peste des petits ruminants viruses
Geographic distribution and epidemiology of peste des petits ruminants viruses
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DOI：
10.1016/0168-1702(96)01312-3
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发表时间：
1996-08-01
期刊：
影响因子：
5
通讯作者：
Barrett, T
中科院分区：
文献类型：
--
作者：
Shaila, MS;Shamaki, D;Barrett, T
小反刍兽疫（PPR）是一种重要的山羊和绵羊病毒性疾病，流行于西非和中东地区。近年来，PPR在印度兴起，先是在南印度，后来在北印度。为了研究不同地理来源的病毒之间的遗传关系，我们对通过逆转录和聚合酶链式反应 (PCR) 扩增生成的融合蛋白基因的 322 核苷酸 cDNA 片段进行了测序。对十九次独立的小反刍兽疫爆发中的病毒进行了比较；其中包括来自塞内加尔的非洲原型毒株以及来自非洲、阿拉伯、近东和印度次大陆不同时期和地点的疾病爆发的病毒。已鉴定出该病毒的四个不同谱系，过去两年从亚洲分离出来的病毒全部属于以前在非洲或亚洲未曾鉴定过的一个谱系。
Peste des petits ruminants (PPR) is an important viral disease of goats and sheep prevalent in West Africa and the Middle Fast. In recent years, PPR has emerged in India, first in the South India and later in North India. To study the genetic relationships between viruses of distinct geographical origin we have sequenced a 322 nucleotide cDNA fragment of the fusion protein gene generated using reverse transcription followed by polymerase chain reaction (PCR) amplification. Viruses from nineteen independent PPR outbreaks were compared; these included the prototype African strain from Senegal and viruses from disease outbreaks which have occurred al different limes and locations across Africa, Arabia, the Near East and the Indian subcontinent. Four separate lineages of the virus were identified and the virus isolates from Asia over the past 2 years were all of one lineage which had not previously been identified in Africa or Asia.