Highly Expressed Genes Are Preferentially Co-Opted for C4 Photosynthesis.
Highly Expressed Genes Are Preferentially Co-Opted for C4 Photosynthesis.
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DOI：
10.1093/molbev/msx269
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发表时间：
2018-01-01
影响因子：
10.7
通讯作者：
Christin PA
中科院分区：
文献类型：
--
作者：
Moreno-Villena JJ;Dunning LT;Osborne CP;Christin PA
新的适应性通常是通过吸收先前存在的遗传成分来组装的，但决定基因是否适合新功能的因素仍然知之甚少。在这项工作中，我们使用比较转录组学来确定增加某些基因被增选用于C4光合作用的可能性的属性，C4光合作用是一种在热带条件下提高生产力的聚合复杂性状。我们发现，独立的谱系草反复增选的基因谱系，是最高度表达的非C4祖先，以产生其C4途径。虽然叶片中祖先的丰度解释了哪些基因用于C4途径的出现，但令人惊讶的是，组织特异性没有影响。我们的研究结果表明，关键基因的水平在草类早期多样化过程中升高，随后通过相对较少的突变反复用于触发弱C4循环。丰富的C4-合适的转录本，因此促进生理创新，但过渡到一个强大的C4途径仍然涉及随之而来的变化，表达水平，叶特异性，和编码序列。强大的C4途径所需的变化的方向和数量取决于增选基因的身份，因此祖先基因的表达既促进了适应性转变，又限制了随后的进化轨迹。
Novel adaptations are generally assembled by co-opting pre-existing genetic components, but the factors dictating the suitability of genes for new functions remain poorly known. In this work, we used comparative transcriptomics to determine the attributes that increased the likelihood of some genes being co-opted for C4 photosynthesis, a convergent complex trait that boosts productivity in tropical conditions. We show that independent lineages of grasses repeatedly co-opted the gene lineages that were the most highly expressed in non-C4 ancestors to produce their C4 pathway. Although ancestral abundance in leaves explains which genes were used for the emergence of a C4 pathway, the tissue specificity has surprisingly no effect. Our results suggest that levels of key genes were elevated during the early diversification of grasses and subsequently repeatedly used to trigger a weak C4 cycle via relatively few mutations. The abundance of C4-suitable transcripts therefore facilitated physiological innovation, but the transition to a strong C4 pathway still involved consequent changes in expression levels, leaf specificity, and coding sequences. The direction and amount of changes required for the strong C4 pathway depended on the identity of the genes co-opted, so that ancestral gene expression both facilitates adaptive transitions and constrains subsequent evolutionary trajectories.
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影响因子：
4.5
作者：
Aubry S;Kelly S;Kümpers BM;Smith-Unna RD;Hibberd JM
通讯作者：
Hibberd JM
影响因子：
6.9
作者：
Braeutigam, Andrea;Schliesky, Simon;Weber, Andreas P. M.
通讯作者：
Weber, Andreas P. M.
影响因子：
3
作者：
Dunn CW;Howison M;Zapata F
通讯作者：
Zapata F
DOI：
10.1111/evo.13250
发表时间：
2017-06
期刊：
Evolution; international journal of organic evolution
影响因子：
--
作者：
Dunning LT;Lundgren MR;Moreno-Villena JJ;Namaganda M;Edwards EJ;Nosil P;Osborne CP;Christin PA
通讯作者：
Christin PA
影响因子：
3.9
作者：
BUDDE, RJA;HOLBROOK, GP;CHOLLET, R
通讯作者：
CHOLLET, R