PCTK Proteins: The Forgotten Brain Kinases?
PCTK Proteins: The Forgotten Brain Kinases?
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DOI：
10.1159/000231895
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Cole, Adam R.
中科院分区：
文献类型：
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作者：
Cole, Adam R.
PCTAIRE激酶（PCTK）是高度保守的丝氨酸/苏氨酸激酶，其与细胞周期蛋白依赖性激酶密切相关。它们在成年大脑的有丝分裂后神经元中富集，表明它们可能独立于细胞周期执行重要的神经元特异性功能。到目前为止，PCTKs在大脑中的生物学功能在很大程度上被忽视，仍有待发现。本文综述了对PCTK激酶活性表达和特征的初步研究，为进一步研究提供了基础。特别是，它确定了进一步研究的三个关键优先领域：（1）PCTK是否需要上游激酶激活磷酸化或与必需辅因子结合以获得最大激酶活性;（2）PCTK的生理底物是什么？（3）PCTK激酶活性在原代神经元中的功能效应是什么？版权所有（C）2009 S. Karger AG，巴塞尔
PCTAIRE kinases (PCTKs) are highly conserved serine/threonine kinases that are closely related to cyclin-dependent kinases. They are enriched in post-mitotic neurons of adult brains, suggesting they might perform important neuron-specific functions independent of the cell cycle. So far, the biological functions of PCTKs in the brain have been largely neglected and remain to be discovered. This review summarises preliminary investigations into the expression and characterisation of PCTK kinase activity, providing a basis for further investigations. In particular, it identifies three key areas of priority for further research: (1) do PCTKs require activating phosphorylation by an upstream kinase or binding to an essential co-factor for maximal kinase activity; (2) what are the physiological substrates of PCTKs, and (3) what is the functional effect of PCTK kinase activity in primary neurons? Copyright (C) 2009 S. Karger AG, Basel