The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis.
The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis.
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作者：
Cazzanelli G;Pereira F;Alves S;Francisco R;Azevedo L;Dias Carvalho P;Almeida A;Côrte-Real M;Oliveira MJ;Lucas C;Sousa MJ;Preto A
利用酵母酿酒酵母作为生物模型，用于研究在多细胞生物体（例如人类）中保守的复杂分子过程，已经允许基本的生物学发现。当比较酵母和人类蛋白质时，很明显，氨基酸序列和蛋白质功能通常都非常保守。RAS家族的成员突出了人类和酵母蛋白之间高度保守的一个例子。事实上，对酵母细胞中RAS调控的信号通路的研究发现了在人类通路中经常与RAS原癌基因互换的特性，反之亦然。在这项工作中，我们对人类和酵母RAS途径进行了更新的关键文献综述，特别强调了它们之间的相似性和差异。此外，我们强调了研究酵母RAS通路对理解人类RAS的贡献，以及这种模式生物如何有助于揭示RAS癌蛋白在调节肿瘤发生过程中重要机制（如自噬）中的作用。
The exploitation of the yeast Saccharomyces cerevisiae as a biological model for the investigation of complex molecular processes conserved in multicellular organisms, such as humans, has allowed fundamental biological discoveries. When comparing yeast and human proteins, it is clear that both amino acid sequences and protein functions are often very well conserved. One example of the high degree of conservation between human and yeast proteins is highlighted by the members of the RAS family. Indeed, the study of the signaling pathways regulated by RAS in yeast cells led to the discovery of properties that were often found interchangeable with RAS proto-oncogenes in human pathways, and vice versa. In this work, we performed an updated critical literature review on human and yeast RAS pathways, specifically highlighting the similarities and differences between them. Moreover, we emphasized the contribution of studying yeast RAS pathways for the understanding of human RAS and how this model organism can contribute to unveil the roles of RAS oncoproteins in the regulation of mechanisms important in the tumorigenic process, like autophagy.
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影响因子：
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作者：
Broach, J R;Deschenes, R J
通讯作者：
Deschenes, R J
影响因子：
5.3
作者：
Apolloni, A;Prior, IA;Hancock, JF
通讯作者：
Hancock, JF
影响因子：
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作者：
Arozarena, Imanol;Calvo, Fernando;Crespo, Piero
通讯作者：
Crespo, Piero
DOI：
10.1016/j.bbamcr.2012.04.016
发表时间：
2012-07-01
影响因子：
5.1
作者：
Belotti, Fiorella;Tisi, Renata;Martegani, Enzo
通讯作者：
Martegani, Enzo
DOI：
10.1007/978-1-4939-6424-6_11
发表时间：
2017-01-01
期刊：
ERK SIGNALING: METHODS AND PROTOCOLS
影响因子：
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作者：
Agudo-Ibanez, Lorena;Crespo, Piero;Casar, Berta
通讯作者：
Casar, Berta