An electrochemical intraocular drug delivery device
An electrochemical intraocular drug delivery device
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DOI：
10.1016/j.sna.2007.06.034
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发表时间：
2008-05-02
影响因子：
4.6
通讯作者：
Meng, Ellis
中科院分区：
文献类型：
--
作者：
Li, Po-Ying;Shih, Jason;Meng, Ellis
研究了一种用于治疗不治之症的微电子机械系统(MEMS)药物输送装置。与传统的眼内给药装置不同，这种MEMS装置能够重新灌装，具有电子控制给药方案的特点，并能够进行有针对性的眼内给药。可再填充的设计允许长期药物治疗，并避免重复手术。剂量的电子控制是通过使用电解驱动的泵将药物直接输送到眼内空间来实现的。灵活的对二甲苯经巩膜插管可以定向输送到眼睛前段和后段的组织。该电化学驱动给药装置可提供适合于眼部药物治疗的流速(Pl/min至Mu L/min)。采用连续给药和团注给药两种给药方式，以实现250nL的目标容量的准确给药。开发了一种用于急性外科研究的胶囊包装技术，并进行了初步的猪眼体外给药实验。(C)2007 Elsevier B.V.保留所有权利。
A microelectromechanical systems (MEMS) drug delivery device is investigated for the treatment of incurable ocular diseases. Unlike conventional ocular drug delivery devices, this MEMS device is capable of being refilled, features electronic control of the drug regimen, and enables targeted intraocular drug delivery. The refillable design permits long-term drug therapy and avoids repetitive surgeries. Electronic control of dosing is achieved by using electrolysis-actuated pumping to deliver pharmaceuticals directly to the intraocular space. A flexible Parylene transscleral cannula allows targeted delivery to tissues in both the anterior and posterior segments of the eye. This electrochemically driven drug delivery device was demonstrated to provide flow rates suitable for ocular drug therapy (pL/min to mu L/min). Both continuous and bolus drug delivery modes were performed to achieve accurate delivery of a target volume of 250 nL. An encapsulation packaging technique was developed for acute surgical studies and preliminary ex vivo drug delivery experiments in porcine eyes were performed. (C) 2007 Elsevier B.V. All rights reserved.