The Mechanistic Role of the Calcium-Activated Chloride Channel ANO1 in Tumor Growth and Signaling.
The Mechanistic Role of the Calcium-Activated Chloride Channel ANO1 in Tumor Growth and Signaling.
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DOI：
10.1007/5584_2016_201
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发表时间：
2017-01-01
影响因子：
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通讯作者：
Alex Gaither, Larry
中科院分区：
文献类型：
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作者：
Bill, Anke;Alex Gaither, Larry
多项研究已经描述了Anoctamin 1（ANO1）在各种癌症中的高表达和扩增，所述癌症包括但不限于乳腺癌、头颈癌、胃肠道间质瘤和胶质母细胞瘤。已证明ANO1通过其调节EGFR信号传导和通路调节剂如MAPK和蛋白激酶B对乳腺癌和头颈癌的肿瘤生长至关重要。然而，ANO1作为钙激活的氯离子通道的发现对该领域来说是一个惊喜，并引起了许多问题。氯离子通道如何促进肿瘤发生？ANO1的氯离子通道功能对其在癌症中的作用重要吗？ANO1在癌细胞中是否表现出不依赖氯的功能？本文综述了目前对ANO1在癌症中的功能的理解，提供了解决该领域中的开放问题的结果的概要，并展望了ANO1作为治疗各种癌症的潜在治疗靶点的前景。
Multiple studies have described the high expression and amplification of Anoctamin 1 (ANO1) in various cancers, including, but not limited to breast cancer, head and neck cancer, gastrointestinal stromal tumors and glioblastoma. ANO1 has been demonstrated to be critical for tumor growth in breast and head and neck cancers through its regulation of EGFR signaling and pathway modulators like MAPK and protein kinase B. However, the discovery of ANO1 as a calcium activated chloride channel came as a surprise to the field and has given rise to many questions. How does a chloride channel promote oncogenesis? Is the chloride channel function of ANO1 important for its role in cancer? Does ANO1 exhibits chloride-independent functions in cancer cells? This review summarizes the current understanding of ANO1's function in cancer, provides a synopsis of the findings addressing the open questions in the field and gives an outlook on the promising future of ANO1 as a potential therapeutic target for the treatment of various cancers.